尖锐湿疣患者皮损及外观正常皮肤表皮中P21^(ras)和c-myc的表达  

Expression of P21^(ras) and c-myc in Lesion and Non-lesion Epidermis of Condyloma Acuminatum

作　　者：庞晓文[1] 赵广[1] 孟如松[1] 张红[1] 

机构地区：[1]中国人民解放军空军总医院皮肤科,北京100036

出　　处：《中国皮肤性病学杂志》2006年第5期264-266,275,共4页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨P21ras和c-myc在尖锐湿疣(CA)发病机理中的作用。方法采用免疫组化二步法检测15例CA损害中P21ras和c-myc的表达情况,并与CA非皮损、正常人表皮及高分化鳞癌皮损组织作对照。结果CA皮损中P21ras阳性细胞广泛分布于基底层、棘层、颗粒层中,在表皮各层中其表达均显著强于正常人组(P<0.05),与CA非皮损组及鳞癌组比较差异无显著性(P>0.05);在CA皮损中c-myc蛋白在表皮各层中的表达均强于正常人组(P<0.05),与CA非皮损组比较差异无显著性(P>0.05),在棘层、颗粒层中的表达则弱于鳞癌组(P<0.05)。结论c-ras是参与细胞信号传导的重要的原癌基因,在CA表皮增殖信号传导过程中发挥重要作用。转录因子c-myc蛋白可直接与DNA作用,促进与增殖有关的基因开放,导致角质形成细胞的过度增殖。Objective To investigate the function of P21^ras and c-myc in pathogenesis of Condyloma Acuminatum （CA）. Methods The expression of P21^ras and c-myc in lesion specimens from 15 patients with CA were examined with immunohistochemistry,compared in non-lesion specimens with CA,normal skin and lesion specimens with Squamous Cell Carcinoma（SCC）. Results The expression level of P21^ras and c-myc in lesion specimens with CA was higher than that in normal skin（ P 〈 0.05 ）. In lesion specimens with CA,the expression level of c-myc in spinal layer and granulous layer was lower than that in lesion specimens with SCC （ P 〈 0.05 ）. Conclusion Our results suggested that increased expression of P21^ras and c-myc in CA is associated with the hyperplasia of CA.

关 键 词：尖锐湿疣 P21^RAS C-MYC 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]