厄贝沙坦合用培哚普利对急性心肌梗死后左室重塑的影响  

Effects of Irbesartan Combined Perdopriol on Left Ventricular Remodeling after Acute Myocardial Infarction

作　　者：张鸿飞[1] 肖立中[2] 林晓云[1] 江志平[2] 

机构地区：[1]韶关大学医院,广东省韶关市512005 [2]广东粤北人民医院心内科

出　　处：《实用心脑肺血管病杂志》2006年第2期104-105,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的观察厄贝沙坦合用培哚普利对急性心肌梗死(AM I)患者左室重塑的影响。方法50例AM I患者随机分为治疗组(26例)和对照组(24例),治疗组在常规治疗基础上加厄贝沙坦及培哚普利,对照组仅加用培哚普利,在第3、6个月时分别采用超声观察左室舒张末期容积指数(LVEDVI)、收缩末期容积指数(LVESVI)、室壁运动指数(WMSI)、射血分数(LVEF)变化。结果2组治疗后,LVESVI、WMSI均减少,LVEF增加,与治疗前相比差异有显著性意义(P<0.05);治疗后治疗组与对照组间比较差异有显著性意义(P<0.05)。结论应用厄贝沙坦合用培哚普利能更有效地防治急性心肌梗死后的左室重塑。Objective To investigate the effects of irbesartan combined perdopriol on left ventricular remodeling after acute myocardial infarction （AMI）. Methods 50 patients with AMI were randomly divided into two groups： treat group （n = 26 ） was treated with irbesartan combined perdopriol on the basis of routine therapy for 6 months, control group （ n = 24） treated with perdopriol alone. In 3th and 6th month after AMI, left ventrictdar end diastolic volume index （LVEDVI）, systolic volume index （ LVESVI）, wall motion score index （ WMSI）, ejection fraction （LVEF） were detected by ultrasonography. Results LVESVI and WMSI were significantly decreased, LVEF was increased after treatment in both treat group and control group （ P 〈 0. 05 ）. There was significant difference in the two groups after treatment （ P 〈 0. 05 ）. Condusion Therapy with irbesartan combined perdopriol can prevent and treat left ventrieular remodeling in patients with AMI more effectively.

关 键 词：心肌梗死 厄贝沙坦 培哚普利 左室重塑 

分 类 号：R542.22[医药卫生—心血管疾病]