壮药解毒蕨提取物对小鼠移植性肿瘤的影响  

Anti-tumor Effect of Jiedujue Extracts of Zhuang Nationality on Mice

作　　者：吕琳[1] 庞声航[1] 陈永红[1] 杨东爱[1] 邓汝铭[1] 曾振东[1] 

机构地区：[1]广西民族医药研究所,广西南宁530001

出　　处：《时珍国医国药》2006年第5期692-693,共2页Lishizhen Medicine and Materia Medica Research

基　　金：广西科技厅攻关课题(No.桂科攻0235022-1A);科技部西部开发科技行动(No.2002BA901A14-A)

摘　　要：目的探讨壮药解毒蕨提取物对小鼠移植性肿瘤的影响。方法从解毒蕨全草中分别制成醇提取物Ⅰ供试液、Ⅱ供试液和水提取物Ⅲ供试液、Ⅳ供试液,以小鼠荷瘤S180,H22,L-1210为模型,将不同浓度的解毒蕨提取物供试液给小鼠灌胃,测算解毒蕨提取物组、模型对照组和环磷酰胺组的肿瘤抑制率、生命延长率。结果解毒蕨乙醇提取物高浓度组(40 g生药/kg-1.d-1)S180抑瘤率为50.84%(P<0.01),H22抑症率为42.67%(P<0.01),L-1210生命延长率为23.44%(P>0.05);低浓度组(20 g生药.kg-1.d-1)S180抑瘤率为38.55%(P<0.05),H22抑瘤率为38.00%(P<0.05),L-1210生命延长率为19.05%(P>0.05)。水提取物高浓度组(40 g生药.kg-1.d-1)S180抑瘤率为25.14%(P>0.05),H22抑瘤率为22.67%(P>0.05),L-1210生命延长率为34.49%(P<0.05);低浓度组(20 g生药.kg-1.d-1)S180抑瘤率为23.46%(P>0.05),H22抑瘤率为21.33%(P>0.05),L-1210生命延长率为30.46%(P<0.05)。结论解毒蕨醇提物能明显抑制小鼠体内移植性肿瘤S180和H22的生长,而且呈现量效关系,水提物有抗小鼠白血病L-1210作用。Objective To study the anti - tumor effect of Jiedujue extracts of Zhuang nationality on mice transplanted tumor cells. Methods Different doses of water and alcohol extracted substances from Jiedujue of Zhuang nationality were given to mice beating S180,H22 ,L-1210tumor. Tumor inhibition rates were determined. Results S180, H22, L-1210 Tumor inhibition rates of the groups with alcohol extracts（40 g crude drug/kg · d） were 50.84% （ P 〈 0.01 ） ,42.67% （ P 〈 0.01 ） ,23.44% （ P 〉 0.05 ） respectively, those of the groups with alcohol extracts（20 g crude drug/kg · d）were 38.55% （ P 〈 0. 05 ）, 38.00% （ P 〈0. 05 ）, 19.05% （P 〉 0.05）, and those of the groups with water extracts （40 g crude drug/kg·d） were 25.14% （P 〉 0.05 ）, 22.67% （ P 〉 0.05 ）, 34.49% （ P 〈 0.05）, those of the groups with water extracts（20 g crude drug/kg · d） were 23.46% （ P 〉 0.05 ）, 21.33% （ P 〉 0.05）, 30.46% （P 〈 0.05 ）. Conclusion The alcohol extracts from Jiedujue of Zhuang nationality have anti -tumor activities on transplanted S^s0,1122 and the tumor inhibition rate was depending on drug concentration. The water extracts from Jiedujue have anti - tumor activities of transplanted L-1210.

关 键 词：解毒蕨 抗肿瘤作用 

分 类 号：R285.5[医药卫生—中药学]