灵芪蠲肝液对大鼠慢性肝损伤氧自由基和一氧化氮的影响  

The Effects of LingQiJuanGan Liquor on Oxygen Free Radicals and NO in Rats with Chronic Liver Damage

作　　者：李万平[1] 李晓冰[1] 肖顺汉[1] 黄兴武[1] 邓存良[2] 陈枫[2] 唐坤华[2] 

机构地区：[1]泸州医学院,四川泸州646000 [2]泸州医学院附属医院,四川泸州646000

出　　处：《时珍国医国药》2006年第5期756-757,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的通过动物实验研究灵芪蠲肝液对慢性肝损伤的防治机理。方法用40%的四氯化碳溶液复制慢性肝损伤模型,取血测定肝功能,血清NO,MDA和SOD,10%肝匀浆的MDA、SOD,并取肝组织做病理学检查。结果四氯化碳慢性肝损伤时,灵芪蠲肝液可降低ALT,AST,MDA,NO,升高ALB及SOD水平,促进肝细胞再生。结论灵芪蠲肝液能减少慢性肝损伤氧自由基和NO,调节蛋白质代谢。Objective To observe the mechanism of LingQiJuanGan （LQL） on hepatic fiborosis by experiments. Methods The model of chronic liver damage was induced by 40% carbon tetrachloride oil liquor. The changes of blood serum ALT, AST,TP, ALB,GLO,ALB/GLO, NO, MDA and SOD were detected;MDA and SOD in liver homogenates were measured; Take liver tissue to do pathological examination. Results LQL can notably decrease ALT, AST, MDA and NO, and reduce fibrous tissus hyperplasia and accelerate liver cell rebirth. Conclusion LQL can reduce production of oxygen free radicals and the NO levels and accommodate metabolism of albumen on CCl4 induced chronic liver damage.

关 键 词：灵芪蠲肝液 慢性肝损伤 氧自由基 一氧化氮 大鼠 

分 类 号：R285.5[医药卫生—中药学]