磁场对小鼠两种迷宫学习记忆的影响  

Effects of low frequency magnetic field on mice learning and memory in Y-maze and Morris water maze

作　　者：王沧恺[1] 宋进毅[1] 王建红[2] 马原野[2] 

机构地区：[1]云南师范大学附属中学,昆明650106 [2]中国科学院昆明动物研究所

出　　处：《现代生物医学进展》2006年第3期11-14,F0003,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目资助(No.30470553);(No.30530270)

摘　　要：据发现,磁场对生物体有一定作用,但是磁场对于人类或实验动物的学习记忆是否有影响,目前的报道结果很不一致本实验采用实验小白鼠,给予不同强度(65高斯/50Hz,35高斯/25Hz)的低频磁场照射(每天1小时,持续25天)。磁场照射后,采用旷场行为测试、Y-迷宫和Morris水迷宫,检测小鼠的活动性、空间辨别、空间学习记忆和非空间学习记忆能力。结果表明:65高斯/50Hz磁场显著增高小鼠的活动性,并损伤小鼠Y-迷宫的空间辨别能力,但对Morris水迷宫的空间、非空间学习记忆无明显影响。35高斯/25Hz磁场处理动物行为在三个指标上均接近对照组。提示:长期的磁场照射可能会给动物,甚至人类造成一些影响。Objective： The magnetic field affects the organisrms in many aspects. However, previous studies showed that effects of the magnetic field on learming and memory in animals are conflicting, in this study, we examined whether two pulsed magnetic fields （65G/50Hz, 35G/25Hz） influenced memory and locomotor activity in ICR mice. Methods： The mice were exposed to different pulsed magnetic fields 1 hour per day for 25 days running, and then they were measured spatial discrimination memory, spatial and non - spatial memory and locomotor activity by using Y- maze, Morris water maze and open- field tests respectivdy. Results： When exposed to 65G/50Hz magnetic field, the locomotor activity increased and spatial discrimination memory impaired in Y - maze, however, showing no effect on performance in Morris water maze, Gompared with control group, mice treated with the 35G/2.SHz magnetic field had similar performance. Conchlsion： Long time low pulsed magnetic field could influence the behavior in mice,even human behavior.

关 键 词：磁场 学习记忆 旷场 MORRIS水迷宫 Y-迷宫 

分 类 号：Q95-337[生物学—动物学] Q958.12