经前平颗粒对经前期综合征肝气逆证患者血清E_2、P峰值的影响  

The influence on Jingqianping granule on E_2 and P peak in serum of PMS with liver-Qi invasion

作　　者：魏霞[1] 张惠云[1] 乔明琦[1] 

机构地区：[1]山东中医药大学,山东济南250014

出　　处：《山东中医药大学学报》2006年第3期198-200,共3页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(项目批准号:90209003)

摘　　要：目的:探讨经前期综合征肝气逆证患者血清雌二醇(E2)、孕酮(P)变化及经前平颗粒(以下简称经前平)对E2、P峰值的影响。方法:病例均于治疗前、后采集月经周期的4个时相血样,用放射免疫法检测血清E2、P含量。结果:该证患者E2增殖期分泌高峰消失、分泌期峰值显著降低;P分泌期高峰阙如。治疗后经前平组E2增殖期、分泌期两个峰值接近正常组,与治疗前比较有显著性差异(P<0.01);P分泌期峰值恢复正常,与治疗前比较有显著性差异(P<0.01)。结论:经前期综合征肝气逆证患者月经周期性激素变化失常,是本证重要微观机制之一。经前平颗粒对性激素周期性变化失调呈现良好纠正作用。Objective： To discuss the change of estradiol （E2） and progestin （P） in serum of premenstmal syndrome （PMS） with liver-Qi invasion and the effect of Jingqianping granule on E2, P. Methods： The blood samples of pre-treatment, in treatment and after treatment were collected, the level of E2. P in serum were examined by using RIA. Results： Excretion pinnacle of E2） disappeared in multiplication period and decreased obviously in excretion period, excretion pinnacle of P disappeared in excretion period, and all the excretion pinnacles of E2 and P are colse to normal after Jingqianping granule treatment, and there is obvious difference from pretreatment （ P 〈 0.01 ）. Conclusion： Periodic turbulence of sex hormone in menstruous cycle is one of the most important microcosmic mechanisms of this syndrome, and Jingqianping granule has favorable function to improve the periodic turbulence of sex hormone.

关 键 词：经前平颗粒 经前期综合征 肝气逆证 雌二醇 孕酮 临床研究 

分 类 号：R256[医药卫生—中医内科学]