生殖激素与睾丸生精功能关系的探讨  

Gelationship between the Levels of Reproductive Hormone in Serum and Testis Spermatogenesis

作　　者：杜久伟[1] 许克义[1] 朱复希[1] 祁新兰[1] 

机构地区：[1]安徽理工大学医学院生殖医学研究所,232001

出　　处：《中国现代医药杂志》2006年第3期4-6,共3页Modern Medicine Journal of China

摘　　要：目的探讨生殖激素与睾丸生精功能的关系及其临床意义。方法用ELISA法测定77例原发性不育症患者血清生殖激素(FSH、LH、PRL、T、INH-B)水平,并对其中FSH高于正常对照组2倍者进行睾丸活检。结果少精组、极度少精组、特发性无精症组FSH、LH水平升高,T/LH比值及INH-B下降,与正常对照相比,差异均具显著性(P<0.01);对27例FSH高于正常对照组2倍者进行睾丸活检,发现中度、重度和不可逆性生精功能障碍依次为3例、10例和14例,FSH水平递增,INH-B水平呈递减趋势,差异具有显著性(P<0.01);重度和不可逆性生精功能障碍患者FSH水平差异无显著性(P>0.05),但INH-B水平差异有显著性(P<0.01)。结论生殖激素水平变化与睾丸生精功能密切相关,如果FSH、LH水平升高,INH-B水平下降,T/LH的比值降低,则提示患者可能生精功能障碍,INH-B似比FSH更能反映出患者生精状态。Objective To study the relationship between the levels of reproductive hormone in serum and testis spermatogenesis and its clinical significances.Methods The levels of FSH, LH, PRL,T and INH-B in serum of 77 male patients with infertility and their biopsy in 27 of 77 patients with more than two times higher levels of FSH than the control group were detected by ELISA and HE stain, respectively. Results The levels of FSH and LH increased in patients with oligozoospermia, severe oligozoospermia and azoospermia and the ratios of T/H and INH-B decreased with significant difference than those in normal controls （P〈0.01）. The high level of FSH and low level of INH-B were explored in the 27 patients with moderate（3 cases）, severe （10 cases）, irreversible dysspermatogenesis （14 cases）, respectively. There was little significant difference among the patients （P〈0.01）. It was similar in the patients with severe and irreversible dysspermatogenesis （P〉0.05）, however, the difference was expressed in the two subgroups （P〈0.01）. Conclusion The levels of hormone in serum is related with testis spermatogenesis, if the levels of FSH and LH increase, the level of inhibin B and the ratio of T/H would be decreased, the dysspermatogenesis should be concluded.

关 键 词：生殖激素 生精功能 不育症 抑制素B 

分 类 号：R698.2[医药卫生—泌尿科学]