不稳定心绞痛血清高敏C反应蛋白与冠状动脉病变程度及近期预后的关系  

Relationship between high-sensitivity C-reactive protein with severity of coronary artery disease and early prognosis in patients with unstable angina pectoris.

作　　者：孙晓红[1] 朱蕾[1] 彭晓玲[1] 

机构地区：[1]深圳市孙逸仙心血管医院,广东深圳518021

出　　处：《临床和实验医学杂志》2006年第2期101-102,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨不稳定心绞痛(UA)患者血清高敏C反应蛋白(hs-CRP)浓度与冠状动脉病变程度和近期预后的关系。方法对215例UA患者进行选择性冠状动脉造影,测定其血清hs-CRP浓度及血糖、血脂、尿酸,分析心血管危险因素及冠状动脉病变与hs-CRP的关系,观察住院期间心血管事件与血清hs-CRP浓度差异。结果UA患者伴有高血压、糖尿病、高胆固醇、吸烟者血清hs-CRP浓度升高,血清hs-CRP浓度与冠状动脉病变的形态及范围相关。发生心血管事件的患者血清hs-CRP浓度明显高于未发生者。结论UA患者血清hs-CRP浓度与高血压、高胆固醇、糖尿病、吸烟心血管危险因素及冠状动脉病变程度相关,hs-CRP水平明显增高者心血管事件发生率高。hs-CRP水平明显增高是不稳定心绞痛发生近期冠脉事件独立的危险预报因子。Objective To investigate the relationship between the concentration of high -sensitivity C -reactive protein （hs -CRP） with the severity of coronary artery disease and the early prognosis in patients with unstable angina （UA）. Methods 215 patients with UA were given selective coronary anglography. The concentrations of hs - CRP and serum cholesterol , glucose and urine acid were measured, Results The increased serum concentration of hs - CRP was observed in the UA patients with hypertension , diabetes and Hypercholesterolemia. The levels of hs - CRP was related to the from and extent of coronary lesion. The hs - CRP concentrations of the patients with cardiovascular events showed significant higher values than those without the events. Conclusion The levels of hs - CRP is related to UA with hypertension , diabetes , hypercholesterolemia and smoking habit, and the severity of coronary artery disease. The level of hs - CRP and the occurrence rate of cardiovascular events are raised remarkably in UA patients. A significant increase in the hs - CRP level is considered an independent predictive factor in early coronary events of the UA patients.

关 键 词：冠状动脉疾病 不稳定心绞痛 高敏C反应蛋白 近期预后 

分 类 号：R541.4[医药卫生—心血管疾病] R542.22[医药卫生—内科学]