P-糖蛋白检测在大肠癌组织中的表达及临床诊断价值  

Expression and clinical diagnosis value of P-glycoprotein in large bowel cancer

作　　者：朱伟东[1] 唐惠君[1] 郑满跃[1] 胡惠军[1] 

机构地区：[1]惠州市人民医院,广东惠州516002

出　　处：《现代医药卫生》2006年第11期1600-1602,共3页Journal of Modern Medicine & Health

摘　　要：目的:探讨P-糖蛋白在大肠癌组织中的表达及临床诊断价值。方法:采用免疫组化SABC法检测P-gp蛋白和CEA在29例大肠癌和30例溃疡性结肠炎标本中的表达情况。结果:在大肠癌组织中P-gp表达的敏感性为65.5%,明显低于CEA的敏感性(96.8%),但P-gp的特异性为86.3%,明显高于CEA的特异性(57.6%)。在溃疡性结肠炎中P-gp表达的阳性率较低,而CEA表达的阳性率高达70%。结论:P-gp蛋白可在结肠组织中异位表达,对大肠癌的诊断特异性强、敏感性高,并可用于预测溃疡性结肠炎病变是否有癌变倾向。Objective：To explore the P-glycoprotein expression and it.s diagnosis value in large bowel cancers. Methods：Immunohistochemical SABC method was used for the detection of P-glycoprotein and CEA in 29 eases of large bowel caneers and 30 ulcerative colitis. Results：The sensitivity of P-glycoprotein in large bowel cancer tissue was 65.5% ,significandy less than that of CEA （96.8%）. But the specificity of P-glycoprotein in large bowel cancer tissue was 86.3% ,significandy more than that of CEA （57.6%）. The positive rate of P-glycoprotein was low in ulcerative colitis,while that of CEA was 70%. Conclusion：P-glycocprotein could ectopicly express in colon, and its diagnosis consists of high sensitivity and good specificity,could predict whether ulcerative colitis had the inclination of going malignant change.

关 键 词：P-糖蛋白 大肠癌 

分 类 号：R446[医药卫生—诊断学]