20味中草药体外对解脲脲原体的抑菌实验研究  

Experimental study on the effect of 20 Chinese herbs on Ureaplasma urealyticum in vitro

作　　者：林平[1] 边保华[1] 陈万平[1] 金彩云[1] 余素飞[2] 金保富[2] 

机构地区：[1]浙江省台州学院医学院,浙江椒江区318000 [2]浙江省台州医院,浙江临海317000

出　　处：《中国麻风皮肤病杂志》2006年第5期375-376,共2页China Journal of Leprosy and Skin Diseases

基　　金：台州学院立项课题;编号:05ND32

摘　　要：目的:探讨解脲脲原体(Uu)对20味中草药的敏感性。方法:用临床分离的Uu为受试菌,采用几何级稀释法测定20味中草药水煎剂的体外最低抑菌浓度(MIC)。结果:20味中草药对Uu均有不同程度的抑菌作用。其中黄柏、蒲公英抑菌效果最好,其MIC范围分别为0.97～7.81和0.97～15.62,MIC50均为3.90,MIC90均为7.81。抑菌效果最差的马齿苋、牡丹皮、鱼腥草敏感率均为0%。结论:本研究提示具有清热燥湿、祛风杀虫之功效的中草药,体外实验对Uu具有不同程度的抑菌作用。由于中草药在体内作用机制比体外还要复杂,在体内能否达到与体外相同效果尚待进一步研究。Objective： To determine the sensitivity of 20 Chinese herbs against Ureaphtsma urealyticum （Uu）. Methods： Minimal inhibitory concentrations （MIC） of 20 Chinese herbs on Uu isolated clinically were determined using geometric - progression diluting method in vitro. Results： All 20 Chinese herbs had bacteriostatic activities against Uu at different extent, among which cortex Phellodendri and herba Taraxaci were highly active against Uu. Their MICs were 0. 97 - 7.81 and 0.97 - 15.62 （ both MIC50 3.90 and both MIC90 7.81 ）. Herba Portulacae, cortex paeoniae and herba Houttuyniae had lowest bacteriostatic action, with a sensitivity rate of 0%. Conclusion： The results suggest that Chinese herbs which can clear away heat, dry dampness and expel wind and parasites may have bacteriostatic effect on Uu in vitro. Because Chinese herb＇ s effects in vivo are more complicated than those in vitro, further studies are needed to determine their effects in vivo.

关 键 词：中草药 解脲脲原体 体外抑菌作用 

分 类 号：R285[医药卫生—中药学]