咪唑斯汀和氯雷他定抗炎作用的比较研究  

Comparative study on anti-inflammfory effect between mizolastine and loratadine

作　　者：应作霖[1] 吴瑞勤[1] 徐晓寅[1] 朱光斗[1] 

机构地区：[1]上海市第一人民医院皮肤科,200080

出　　处：《中国麻风皮肤病杂志》2006年第5期377-379,共3页China Journal of Leprosy and Skin Diseases

基　　金：中华医学会皮肤性病学分会皮肤科研究基金资助

摘　　要：目的:检测咪唑斯汀的抗炎活性,探讨咪唑斯汀抗炎症的作用机制。方法:建立花生四烯酸诱导小鼠耳部肿胀的模型,了解咪唑斯汀和氯雷他定对花生四烯酸诱导的耳部肿胀的抑制作用;同时用酶免疫法检测小鼠血液中的白三烯浓度。建立角叉菜胶诱导的大鼠鼠爪肿胀模型,了解咪唑斯汀和氯雷他定对角叉菜胶诱导的炎症的抑制作用。结果:咪唑斯汀可抑制花生四烯酸诱导的耳部水肿,对角叉菜胶诱导的鼠爪水肿无抑制作用;但氯雷他定对两种致炎剂诱导的水肿均无抑制作用。结论:咪唑斯汀具有显著的抗炎作用,其机制是抑制5-脂氧合酶的活性,阻止白三烯的产生而发挥其抗炎活性。Objective： To detect anti - inflammatory activity of mizolastine and study its mechanism of anti - in- flammation. Methods： After development of a mouse mode of arachidonic acid - induced ear edema the anti - edematous effect of mizolastine or loratadine in arachidoni acid - induced ear edema was studied, the leukotriene concentration in the blood of mouse detected by enzyme - i mmunoassay. The reaction of edema in rat paw was induced by carrageenan to study the anti - edematous effect of mizolastine or loratadine in this model. Results： Mizolastine significantly inhibited arachidonic acid- induced ear edema while showed no inhibitory effect on carrageenan - induced edema, Loratadine had no significant inhibitory effect on arachidonic acid and carrageenan- induced edema. Conclusion： Mizolastine has an apparent anti - inflammatory effect. Its mechanism of anti - inflammation is to inhibit the activity of 5 - lipaxygenase and production of leukotriene.

关 键 词：咪唑斯汀 氯雷他定 白三烯 炎症 5-脂氧合酶 抗炎作用 

分 类 号：R96[医药卫生—药理学]