鲍曼不动杆菌耐药性动态变化特征及分析  

Changes in resistance rates of acinetobater baumannii:characteristircs and analysis

作　　者：李丰良[1] 袁嘉丽[2] 刘海云[1] 杜廷义[1] 郑瑞[1] 曾光雄[1] 

机构地区：[1]云南省第一人民医院检验科,昆明650032 [2]云南中医学院基础学院微生物教研室,昆明650021

出　　处：《国际检验医学杂志》2006年第5期388-390,共3页International Journal of Laboratory Medicine

基　　金：云南省自然科学基金项目(2001C0052M)

摘　　要：目的分析该院6年来鲍曼不动杆菌耐药性变化，为临床合理使用抗生素提供依据。方法采用K—B纸片扩散法对临床标本分离的鲍曼不动杆菌进行抗菌药物敏感性测定，数据输入WHONET5．3软件进行统计分析。结果在统计年限内，共检出鲍曼不动杆菌309株，分离率逐年上升。鲍曼不动杆菌对常用抗生索的耐药率有普遍上升的趋势并呈多重耐药。其中对亚胺培南耐药率最低（3．6％），对阿米卡星、耐替米星、左旋氧氟沙星、头孢哌酮／舒巴坦、头孢吡肟、哌拉西林等抗菌药物耐药率在29．5％～77．4％之间。结论鲍曼不动杆菌临床分离率逐年增加，耐药性逐年增强，应加强其耐药率监测，合理使用抗生素。Objective To investigate the trend of omtibacterial resistance rate of Acinetobater baumannii in our hospital from Jan, 2000 to Jun. 2005, and for the guidance of rational use of antibacterials. Methods A. baumannii strain was isolated and tested by K-B method from clinical samples and antibiotic resistance was analyzed and studied retrospectively. Results There was an elevated tendency of the resistance rates to common antibacterial in A baumanii for past six years. The resistance rate to imipenem was the lowest （3.6%） and to amikaein, cefoperazone/sulbaetam was 29. 5%- 77.4%. Conclusion The resistance rates to common the antibacterial in A. baumanii are high and the resistance pattern is wide. It is important to select antibiotics according to the antibiotics sensitivity in vitro.

关 键 词：鲍式不动杆菌 分离率 抗菌药 抗药性 细菌 

分 类 号：R446.5[医药卫生—诊断学]