妊娠期肝内胆汁淤积症的临床干预对围生儿预后的影响  

Impact of Clinical Intervention on Prognosis of Neonates with Intrahepatic Cholestasis in Pregnancy

作　　者：王茜霞[1] 张晓星[1] 高坚容[1] 

机构地区：[1]西安市第四医院,陕西西安710002

出　　处：《实用妇产科杂志》2006年第5期301-303,共3页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:探讨妊娠期肝内胆汁淤积症(ICP)的临床干预对围生儿预后的影响。方法:分析比较70例ICP患者干预治疗前后,与同期未作过任何干预的48例ICP患者的临床症状、肝功能指标及围生儿结局进行比较。结果:观察组治疗后瘙痒评分、血清胆汁酸、总胆红素、直接胆红素、谷丙转氨酶、谷草转氨酶等生化指标较治疗前明显下降(P<0.01)。与对照组比较观察组孕周较长,新生儿体重较重,胎儿窘迫、羊水粪染、早产儿、新生儿窒息发生率降低(P<0.01)。但低体重儿、围生儿死亡发生率无明显改变,两者比较无显著差异(P>0.05)。结论:积极正确处理妊娠期肝内胆汁淤积症可明显减轻孕妇的瘙痒症状,降低围生儿的胎儿窘迫、羊水粪染、新生儿窒息等的发生率,提高围生儿的生存质量。Objective： To investigate the impact of clinical intervention on prognosis of neonates with intrahepatic cholestasis in pregnancy （ICP）, Methods： The clinical symptoms of 70 pregnant women with ICP and biochemical parameter of their neonates were observed before and after clinical intervention, another 48 cases of ICP without intervention were taken as control, Clinical symptoms, hepatic function parameters and neonatal outcomes of both groups were recorded. Results： After antenatal treatment, there were significant decreases on the degree of itchy symptoms and the matemal blood level of biochemical parameters such as TBA, TBIL, DBIL, GPT and GOT （ P 〈 0. 05）. Compared with untreated group, the pregnancy period of the treated group was significant prolonged, the weight of newboms was increased and the incidence of fetal distress, meconium passage, preterm delivery, neonatal asphyxia were greatly decreased （ P 〈 0.01 ）, However, ;the incidence of low birth weight infant and neonatal death rate had no statistical difference between the two groups （ P〉 0.05）. Conclusions： Intensive care and proper treatment make it possible to alleviate itchy symptoms of the pregnant women with ICP,to decrease the rate of fetal distress, meconium passage and neonatal asphyxia, and to improve the outcome of neonates.

关 键 词：妊娠期胆汁淤积症 干预 围生儿预后 

分 类 号：R714.255[医药卫生—妇产科学]