生物发光技术在活体成像检测中的应用  

Application of in vivo Bioluminescence Imaging Technology

作　　者：尉继征[1] 熊伟[1] 祝庆余[1] 

机构地区：[1]军事医学科学院微生物流行病研究所病原微生物生物安全国家重点实验室,北京市100071

出　　处：《医学分子生物学杂志》2006年第3期237-240,共4页Journal of Medical Molecular Biology

基　　金：北京市自然科学基金(No.7042051)~~

摘　　要：生物发光体内成像检测技术已广泛应用于许多动物实验中,其优势在于可对特定的细胞和分子行为进行非侵入性的体内评价和连续动态研究,这些细胞和分子往往是药物作用或基因治疗的靶点。该技术有效减少了所需实验动物的数量,也减小了因个体差异引起的误差,改进了数据点的质量。In vivo bioluminescence imaging technology has been effectively incorporated into animal research protocols. It has great advantage of noninvasive in vivo assessment of the molecular and cellular events that are often targets of drug or gene therapy, and these events can be studied in individual animals over time. This reduces the number of animals required for a given study and im- proves the data set as the temporal data allows for each animal to serve as its own internal control.

关 键 词：生物发光技术 体内成像 报告基因 荧光素酶 

分 类 号：Q78[生物学—分子生物学]