一种新手性配体的合成及其锇配合物的催化作用  

Synthesis of a Novel Chiral Ligand and Catalysis of the Ligand-OsO_4

作　　者：王巧峰[1] 丁愉[2] 祝春来[2] 薛小燕[2] 孙晓莉[1] 

机构地区：[1]第四军医大学药学系 [2]第四军医大学学员旅12队,陕西西安710032

出　　处：《合成化学》2006年第3期249-252,共4页Chinese Journal of Synthetic Chemistry

基　　金：陕西省自然科学基金资助项目(2005B03)

摘　　要：以1，4-二氯-2，3-二氮杂萘为原料，经两步反应合成了一种新的金鸡纳生物碱衍生物手性配体2，其结构经^1H NMR，^13C NMR和MS表征。OsO4-2用于催化烯烃的不对称双羟化反应，化学产率91％～94％，e．e．值93％～99％；用于催化烯烃的不对称氨羟化反应，收率45％～63％，e．e．值83％～95％。A novel chiral ligand（ cinchona alkaloid derivative） was easily prepared from 1,4-dichlo- rophthalazine by a two-step reaction. The structure was characterized by ^1H NMR, ^13C NMR and MS. Application of the ligand-OsO4 in the asymmetric dihydroxylation reaction of several olefins afforded corresponding chiral diols in yield of 91% -94% and 93% e.e.-99% e.e., while the results for asymmetric aminohydroxylation reaction of olefins were 45% -63% yield and 83% e.e.-95% e.e..

关 键 词：金鸡纳生物碱衍生物 手性配体 不对称双羟化反应 不对称氨羟化反应 合成 催化作用 

分 类 号：O629.3[理学—有机化学] O643.32[理学—化学]