正交试验优选复方银杏叶片的处方研究  

Optimization of the Formula of Compound Ginkgo Leaves Tablets by Orthogonal Experiment

作　　者：危华玲[1] 潘洪平[1] 卢文胜[2] 

机构地区：[1]广西壮族自治区人民医院,南宁市530021 [2]广西医科大学附属第三医院,南宁市530031

出　　处：《中国药房》2006年第10期736-737,共2页China Pharmacy

基　　金：广西科学基金资助项目(桂科基0342003-1)

摘　　要：目的:筛选复方银杏叶片的最佳处方。方法:采用正交设计试验,以多指标(片重差异、崩解度)综合评分法,筛选最佳处方(低取代羟丙基纤维素用量、原料药与填充剂的用量比例、微晶纤维素用量)。结果:最佳处方系低取代羟丙基纤维素用量为5%,原料药与填充剂的用量比例为1∶1,微晶纤维素用量为10%。结论:该片剂处方合理,且片剂成型质量好。OBJECTIVE： To optimize the formula of the compound ginkgo leaves tablets, METHODS： The formula （dosage of low- substituted hydroxypropyl cellulose; the ratio between crude drug and loading agent and the dosage of microcrystalline cellulose） was optimized using orthogonal design and multi - index （tablet weight variation and disintegration degree） comprehensive score method. RESULTS： The optimized formula was the following： the dosage of low-substituted hydroxypropyl cellulose was 5% ; the ratio between crude drug and loading agent was 1 ： 1 and the dosage of microcrystalline cellulose was 10%. CONCLUSION： The tablets are reasonable in formula and the forming quality of which is also good.

关 键 词：正交试验 复方银杏叶片 处方 

分 类 号：R94[医药卫生—药剂学]