BCEF0083对慢性应激抑郁模型大鼠海马神经元及脑源性神经营养因子mRNA表达的影响研究  

Effects of BCEF0083on Hippocampus Neurons and mRNA Expression of BDNF in Chronic Stress Depression Rat Models BCEF0083

作　　者：程燕[1] 明亮[1] 周兰兰[1] 江琴[1] 

机构地区：[1]安徽医科大学药理教研室,合肥市230032

出　　处：《中国药房》2006年第10期738-740,共3页China Pharmacy

基　　金：安徽省科技厅自然科学基金资助课题(44415)

摘　　要：目的:研究BCEF0083对慢性应激抑郁模型大鼠海马神经元及脑源性神经营养因子(BDNF)mRNA表达的影响。方法:将大鼠随机分为对照组、模型组、吗氯贝胺20mg/kg组以及BCEF0083100、50、25mg/kg组,用HE染色法观察海马神经元数目的变化,用逆转录-聚合酶链反应法检测海马BDNFmRNA的表达。结果:BCEF0083可增加慢性应激抑郁模型大鼠海马神经元数目及上调BDNFmRNA的表达。结论:BCEF0083的抗抑郁作用可能与增加慢性应激抑郁模型大鼠海马神经元数目及上调BDNFmRNA的表达有关。OBJECTIVE： To explore the effects of bioactive compounds from entomogenous fungi （BCEF0083） on hippocampus neurons and mRNA expression of BDNF in chronic stress depression rat models. METHODS： The selected rats were randomly divided into control group, model group, moclobemide 20mg/kg group, and BCEF0083 100, 50, 25mg/kg groups. The change in hippocampus neuron numbers were observed by HE staining and mRNA expression of BDNF was detected with RT - PCR. RESULTS： BCEF0083 could increase the neuron numbers and up - regulate the expression of BDNF mRNA in hippocampus. CONCLUSION： The antidepressant effect of BCEF0083 in chronic stress depression rat models is probably related to the increase in hippocampus neuron numbers and up - regulation of expression of BDNF mRNA in hippocampus.

关 键 词：慢性应激 抑郁模型 大鼠 海马 神经元 脑源性神经营养因子 

分 类 号：R965[医药卫生—药理学]