脓毒症患者血清IL-6水平检测的临床评价  

The clinical value of detecting the interleukin-6 levels in serum in the patients with sepsis

作　　者：赵有成[1] 南琼[2] 柯青[3] 魏宏建[2] 段勇[2] 

机构地区：[1]浙江省人民医院麻醉科,浙江杭州310014 [2]昆明医学院附一院 [3]解放军总医院

出　　处：《中国医师杂志》2006年第5期608-610,共3页Journal of Chinese Physician

摘　　要：目的揭示血清白细胞介素6(IL-6)水平在脓毒症患者体内变化规律及意义。方法分别抽取40例APACHEⅡ评分>12分的脓毒症患者和30例正常人的外周血,应用放射免疫分析法检测其血清IL-6水平。将这2组血清IL-6水平进行比较。同时将脓毒症组的IL-6水平与病人的预后、APACHEⅡ评分作相关性分析。结果脓毒症组血清IL-6水平[(152.02±55.77)pg/m l],与正常对照组IL-6[(85.79±30.96)pg/m l]比较差异有统计学意义(P<0.01)。脓毒症组血清IL-6水平与病人的预后呈正相关(r=0.667,P=0.000),与APACHEⅡ评分呈正相关(r=0.485,P=0.002)。40例感染患者中有20例死亡,他们的血清IL-6水平[(186.20±48.74)pg/m l]较生存病例[(117.84±39.36)pg/m l]高(t=4.880,P=0.000)。结论脓毒症时,血清IL-6水平升高,其升高反应了感染的严重程度,与预后有较好的相关性。Objective To investigate the regularity and significance of serum interleukin-6 （IL-6） levels in the patients with sepsis, Methods Forty sepsis patients with APACHE Ⅱ scores over 12 and 30 normal controls were involved in the study, The IL-6 levels in serum were detected with radio-immunity analysis assay and the correlations among the IL-6 levels, the prognosis and APACHE Ⅱ score were investigated. Results In the patients with sepsis, the average level of IL-6 in serum was （ 152. 02 ± 55, 77 ） pg/ml, which was significantly higher than that of the control group [ （85.79 ±30, 96） pg/ml] （ P 〈0. 01 ）, In the patients with sepsis, there was a positive correlation between the IL-6 levels and the prognosis（ r = 0. 667, P =0. 000） ,and the IL-6 levels were positively correlated with the APACHE Ⅱ score （ r = 0, 485, P = 0. 002 ）. Among 40 patients with sepsis, 20 patients were dead and the IL-6 level in the 20 patients [ （ 186, 20 ± 48.74） pg/ ml] were higher than that of the survivors [ （ 117.84 ±39. 36） pg/ml ] （ t = 4. 880, P = 0. 000）, Conclusion The IL-6 levels are increased in the serum of the patients with sepsis and there is a positive correlation between the IL-6 levels and prognosis.

关 键 词：脓毒症 白细胞介素6 血清 临床评价 

分 类 号：R631[医药卫生—外科学]