LDH,CKMB变化对评价扩张型心肌病预后的价值  

Values of LDH and CKMB in evaluating the prognosis of idiopathic dilated cardiomyopathy

作　　者：郑小璞[1] 马爱群[1] 王锐[1] 张炜[1] 

机构地区：[1]西安交通大学医学院第一附属医院心血管内科,环境与疾病相关基因教育部重点实验室,陕西西安710061

出　　处：《第四军医大学学报》2006年第10期914-916,共3页Journal of the Fourth Military Medical University

摘　　要：目的观察68例扩张型心肌病心力衰竭患者LDH,CKMB在心力衰竭中的变化规律及其与预后的关系.方法检测病程<1a组、病程1a组、生存组及死亡组LDH,CKMB的变化.LDH采用酶连续法测定,CKMB采用免疫抑制法测定.结果无论病程长短,LDH均高于对照组,随病程延长而增高,以死亡组为著;CKMB在病程<1a组,显著高于对照组,但随病程的延长反而明显降低,以死亡组为著.结论扩张型心肌病心力衰竭患者LDH,CKMB变化可能与心室重构及心肌能量代谢障碍有关.LDH持续升高,CKMB随病程延长而下降,或短期内CKMB明显升高,均提示预后不良.AIM： To analyze the changes in concentrations of LDH, CK-MB in 68 patients with idiopathic dilated cardiomyopathy （DCM） , and the correlation between the concentrations of LDH, CKMB and the prognosis of DCM. METHODS： LDH, CKMB were measured with continuous enzyme-linked assay and immunosuppressive method respectively in following groups： the normal control group, the duration of DCM 〈 lyear group and the duration of DCM ≥ 1 year group, the survival group and the death group. RESULTS： The level of LDH was significantly higher in each group than that in the control group, especially in the duration of DCM ≥ 1 year group and the death group （ P 〈 0.05 ）. The level of CKMB was significantly higher in the duration of DCM 〈 lyear group than that in the control group （ P 〈 0.05 ）, and was significantly reduced with the development of DCM, especially in the death group. COUCLUSION： The changes in concentrations of LDH, CKMB in patients with DCM appear to be associated with myocardial remodeling and the disturbance of energy metabolism. Persistently increased concentration of LDH, gradually reduced concentration of CKMB, and rapidly increased level of CKMB in a short-term, all indicate the poor prognosis of the DCM patients.

关 键 词：心肌病 充血性 心力衰竭 心肌/酶学 

分 类 号：R541.6[医药卫生—心血管疾病]