两种谷胱甘肽过氧化物酶模拟物抗紫外线损伤的研究  

Two GPX Mimics Protecting Thymocytes from Damage Induced by UV

作　　者：吕绍武[1] 牟颖[1] 籍月彤[1] 张代辉[1] 闫岗林[1] 罗贵民[1] 

机构地区：[1]吉林大学分子酶学工程教育部重点实验室,长春130021

出　　处：《吉林大学学报（理学版）》2006年第3期497-500,共4页Journal of Jilin University:Science Edition

基　　金：国家自然科学基金(批准号:200072010;30200050).

摘　　要：考察了紫外线照射小鼠胸腺细胞后,对细胞存活率、细胞周期、细胞凋亡、脂质过氧化程度以及外源性活性氧含量变化的影响,表明紫外线对胸腺细胞有严重损伤.研究了谷胱甘肽过氧化物酶(GPX)的模拟物2-硒桥联β-环糊精和2-碲桥联β-环糊精抵抗紫外线损伤细胞的能力,结果表明,GPX模拟物能有效地保护细胞,防止紫外线引起的损伤.Effects of glutathione peroxidase （GPX） mimics （ 2-selenium-bridged β-cyclodextrin, 2-telluriumbridged β-cyclodextrin） on lipid peroxidation, survival ratio, cell cycle and external reactive oxygen species （ROS） content in rat thymocytes, which were radiated by UV-B, were studied invitro. The 2-SeCD and 2-TeCD can efficiently resist the to prevent thymocyte from UV-B damage induced by UV. It was found that 2-TeCD possessed a stronger ability damage in comparison with 2-SeCD.

关 键 词：谷胱甘肽过氧化物酶 2-SeCD 2-TeCD 模拟物 紫外线 

分 类 号：R392.11[医药卫生—免疫学]