麻黄素预防异丙酚诱导注射痛和低血压的临床观察  

The clinical observation of preventing propofol- induced injection pain and hypotension by ephedrine

作　　者：傅小云[1] 王德明[1] 

机构地区：[1]南华大学附二院麻醉科,衡阳421001

出　　处：《贵州医药》2006年第3期208-210,共3页Guizhou Medical Journal

摘　　要：目的探讨麻黄素预防异丙酚诱导时注射痛和低血压的效果。方法90例ASA分级为Ⅰ-Ⅱ级自愿接受异丙酚麻醉的门诊人工流产手术早孕妇女,随机分为三组:麻黄素组(n=30), 异丙酚注射前30s给予麻黄素30μg／kg(麻黄素以生理盐水稀释至2ml);利多卡因组(n=30),异丙酚注射前30s给予2％利多卡因2ml;对照组(n=30),异丙酚注射前30s给予生理盐水2ml。观察每组疼痛发生率和根据McCrirrick与Hunter的VRS(verbal rating scale)进行疼痛评分,记录诱导前后平均动脉压(MAP)的变化。结果麻黄素组、利多卡因组异丙酚注射痛的发生率和疼痛评分明显低于对照组(P<0．01),麻黄素组诱导后2分钟血压明显高于利多卡因组和时照组(P<0．01)。结论异丙酚诱导时预注麻黄素可减轻注射痛,预防异丙酚诱导时引起的低血压。Objective To research the effects of ephedrine on preventing propofol--induced injection pain and hypotension. Methods 90 cases （ASAⅠ～Ⅱ ） from outpatient clinic induced abortion by propofol anesthesia were divided into three groups, Ephedrine group （301 received ephedrine 30 μg/ kg, lidocain group （301 received 2% lidocain 2 ml; Control group received saline 2ml, 30 seconds before propofol injection （2 mg/kg）. Patients were asked to evaluate the pain score according to verbal rating scale and face pain scale. Mean arterial pressures were recorded preoperatively, after 2 re.in propofol injection. Results The incidence and intensity of pain were less in lidocain group and ephed rine group than in control group （P〈0. 01）. The mean arterial pressure in ephedrine group 2 min after propofol injection was significantly higher than that of lidocain group and control group （P〈0. 011. Conclusion Ephedrine can prevent and decrease injection pain and hypotesion from propofol anesthesia.

关 键 词：异丙酚 麻黄素 注射痛 低血压 

分 类 号：R614.1[医药卫生—麻醉学]