壮尔颗粒对小鼠细胞免疫功能的影响  

Effect of Zhuang'er Granules on Cellular Immune Function of Mice

作　　者：宋铁玎[1] 李红[2] 王雪峰[1] 张君[1] 程嘉艺[2] 

机构地区：[1]辽宁中医药大学附属医院,沈阳110032 [2]辽宁中医药大学,沈阳110032

出　　处：《中药新药与临床药理》2006年第3期177-179,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：辽宁省沈阳市科技局重点项目"中药壮尔颗粒治疗反复呼吸道感染的新药研究"(1032041-1-04)

摘　　要：目的观察壮尔颗粒(Zhuang'erGranules,ZG)对小鼠细胞免疫功能的影响。方法用氢化可的松建立免疫抑制小鼠模型,灌胃7d后,采用体外法测定小鼠巨噬细胞吞噬功能,形态学检测法测定小鼠淋巴细胞转化率。结果与对照组相比较,ZG对正常小鼠和免疫抑制小鼠均具有显著增强巨噬细胞吞噬功能和提高淋巴细胞转化百分率的作用(P<0.05),且作用呈量效关系。结论ZG具有一定的提高小鼠细胞免疫功能的作用。Objective To study the effect of Zhuang＇er Granules （ZG） on cellular immune function of mice. Methods The immunodepression mice models were induced by injection of hydrocortisone. Then the lymphocyte transformation rate was examined by morphological test and phagocyte phagocytosis by in vitro method after 7 - day intragastric administration of the drugs. Results Compared with the negative control group, mation rate and phagocyte phagocytosis in the normal mice and ZG could significantly improve the lymphocyte transforimmunodepression mice （ P 〈 0. 05） in a dose - effect manner. Conclusion ZG has a certain effect in advancing cellular immune function of mice.

关 键 词：壮尔颗粒 细胞免疫 巨噬细胞吞噬功能 淋巴细胞转化率 小鼠 

分 类 号：R285.5[医药卫生—中药学]