长期有规律的体育运动对老年人I型和Ⅱ型T细胞因子平衡的影响  

The effect of long term and regular physical exercise on the balance of type I and type Ⅱ T cytokines in the elderly

作　　者：黄腊秀[1] 陈小武[2] 

机构地区：[1]咸宁学院体育系,湖北咸宁437100 [2]咸宁学院医学院解剖教研室,湖北咸宁437100

出　　处：《体育学刊》2006年第3期54-57,共4页Journal of Physical Education

摘　　要：为了检验长期习惯性的体育运动是否影响老年人I型和Ⅱ型T细胞因子的平衡。通过对9名老年妇女(平均年龄(63±1)岁,最大耗氧量(32.2±1.0)mL.kg-1.min-1)进行步行训练;挑选12名不进行运动训练的老年(妇女平均年龄(63±1)岁,最大耗氧量(27.8±0.9)mL.kg-1.min-1)和9名不进行运动训练的年轻妇女(平均年龄(26±1)岁,最大耗氧量(37.8±1.3)mL.kg-1.min-1);然后检测了CD4+和CD8+T细胞中IFN-γ、IL-2和IL-4的水平,并对I型和Ⅱ型T细胞进行了比较。结果:老年人运动组表达IFN-γ的CD4+细胞数目与比青年非运动组比较,差异有显著性(P<0.01);老年运动组表达IL-2的CD8+的T细胞数目与老年非运动组比较差异有显著性(P<0.05);青年组表达IL-4的CD8+细胞与老年非运动组比较,差异有显著性(P<0.01);3组中CD4+和CD8+T细胞中IFN-γ/IL-4的比率差异无显著性。实验结果显示年龄对I型和Ⅱ型T细胞的影响比运动训练对它的影响更大。The purpose of this study was to test the hypothesis that regular exercise training in elderly people affects the type 1/type 2 balance. Methods Nine elderly women who train by walking （63 ± 1 ） a, VO2max=（32.2 ± 1.0） mL·kg^-1·min^-1 ）, 12age - matched untrained women （63 ± 1 ） a, VOmax= （27.8 ± 0.9） mL·kg^-1·min^-1, and nine young untrained women （26 ± 1 ） a, VO2max （37.8 ± 1.3） mL·kg^-1·min^-1 participated in the study. We measured interferon γ （ IFN - γ）, IL - 2, and IL - 4 in CD4 ± and CD8 ± T cells, to compare type 1 and type 2 T cells. Restdts the number of CD4 ± cells expressing intracellular IFN - γ（CD4 ±//IFN - γcell） significantly higher in the elderly trained than in the young（ P 〈 0.01 ）. The number of CD8 ±/IL - 2 cells was significantly higher in the elderly trained than in the elderly untrained（ P 〈 0.05）. The number of cells was significantly higher in the young than in the elderly untrained（ P 〈 0.01 ）. No significant differences were apparent in the IFN - γ/IL- 4 ratio within CIM ± and CD8 ± cells from the three groups. Conclusion These results might indicate that the effect of age on the balance of type 1/type 2 T cells was stronger than the effect of physical training.

关 键 词：运动 免疫 T淋巴细胞 最大耗氧量 老年人 

分 类 号：G804.7[文化科学—运动人体科学]