孕激素对应激性胃溃疡的保护和治疗作用  

THE PROTECTIVE AND THERAPEUTIC OF PROGESTERONE IN STRESS GASTRIC ULCERS

作　　者：孙海基[1] 潘维锋[1] 许松龄[1] 杨恩展[1] 伊文婧[1] 杨忠诚[1] 

机构地区：[1]山东师范大学生命科学学院,济南250014

出　　处：《山东师范大学学报（自然科学版）》2006年第2期112-114,共3页Journal of Shandong Normal University(Natural Science)

基　　金：山东省自然科学基金(Y97D18077)项目资助

摘　　要：目的探讨孕激素对应激性胃溃疡的保护和治疗作用.方法小鼠分组,注射生理盐水及不同剂量的孕激素后,束缚加冷水刺激,计算溃疡指数及测定胃酸的pH值;束缚加冷水刺激后,注射生理盐水及孕激素,于应激后即刻、应激后5h、应激后7h计算溃疡指数.结果发现应激前注射孕激素对胃溃疡有明显的预防和保护作用;而溃疡发生后,注射孕激素有较好的治疗作用.The protective and therapeutic role of progesterone in gasric ulcers induced by restrain plus water - immersion stress is explored. Mice were divided into groups, restrained and put them into cold - water by 3 hours to induce gastric ulcer. Progesterone was administrated 30 min before and soon after the onset of stress, then measured the gastric ulcer index and the hydrochloric acid in gastric juice. Compared with the eomtrol group, which was administrated with saline, the mice administrated with progesterone before and after stress, were remarkably low in ulceration. These show that progesterone plays a protective and therapeutic role in restrain plus water- immersion stress induced gastric ulcers.

关 键 词：胃溃疡 孕激素 束缚加冷水 

分 类 号：Q4[生物学—生理学]