益智药乙拉西坦的合成和结构表征  

Synthesis and Structural Characterization of Nootropics Etiracetam

作　　者：旷春桃[1] 胡艾希[2] 

机构地区：[1]中南林业科技大学工业学院,湖南长沙410004 [2]湖南大学化学化工学院,湖南长沙410082

出　　处：《中南林学院学报》2006年第2期129-130,137,共3页Journal of Central South Forestry University

摘　　要：以2-溴丁酸甲酯为起始原料,经氨解反应、N-烷基化反应合成了乙拉西坦,总收率为45.6%,改进后的工艺路线反应时间缩短、收率提高;并用IR、1H NM R、13C NM R对乙拉西坦进行了结构表征.Etiracetam was synthesized from methyl 2-bromobutyrate by aminolysis and N- alkylation. The overall yield was 45.6%. The improved process, with a higher yielding and shorter reaction time, is better than any reported process in literatures. Its structure was confirmed by IR,^1H NMR and ^13C NMR.

关 键 词：乙拉西坦 合成 2-溴丁酸甲酯 2-吡略烷酮 表征 

分 类 号：R914.5[医药卫生—药物化学]