淮北地区肠杆菌科细菌对21种抗生素的耐药性分析  

Analysis on enterobacter resistance to 21 antibiotics in Huaibei area

作　　者：张琪[1] 程训民[1] 朱素珍[1] 李敏[1] 

机构地区：[1]安徽省淮北市人民医院检验科,235000

出　　处：《蚌埠医学院学报》2006年第3期295-296,共2页Journal of Bengbu Medical College

基　　金：安徽省淮北市科技局科研资助项目(030131)

摘　　要：目的:了解21种抗生素对淮北地区肠杆菌科细菌的体外抗菌活性,指导临床有效合理用药。方法:收集淮北地区分离的326株肠杆菌科细菌,采用M icro Scan W alkAway-40、V itek-32全自动微生物分析仪和K-B法进行菌种鉴定和耐药性分析,按照1999年NCCLS的标准进行结果判断。结果:在检测的326株肠杆菌科细菌中,分离出大肠埃希菌216株,肺炎克雷伯菌37株,鼻硬结克雷伯菌18株,聚团多源菌19株,产气肠杆菌18株,阴沟肠杆菌18株。大肠埃希菌、肺炎克雷伯菌等对亚安培南的耐药率最低,分别为1.4%和2.8%。其次为哌拉西林/他唑巴坦和头孢哌酮/舒巴坦,另外庆大霉素和阿米卡星耐药率也较低。结论:所测试的21种抗生素中亚安培南是治疗的首选药物,临床治疗时应根据具体菌种及实验室药敏结果合理选择抗生素。Objective ：To analyze and compare the anti-bacterial effects of 21 antibiotics on the nitrobacteria isolated from 3 hospitals in Huaibei area in order to direct proper use of drugs in clinics. Methods： A total of 326 nitrobacteria were tested by Micro Scan WalkAWay-40,Vitek-32 and Kirby-Beuer for drug sensitivity. The susceptibility test was conducted according to NCCLS formulated in 1999. Results： Among 326 strains of enterobacteriaceae were isolated Escherichia coli （ 216 ）, Klebsiella pneumoniae （ 37 ）, Klebsiella rhinoschleromatis （ 18）, Enterobacter agglomerans （ 19 ）, Enterobacter aerogenes （ 18 ） and Enterobacter cloacae （ 18 ）. Escherichia coli and Klebsiella pneumoniae resistance to imipenem were the lowest（ 1.4% and 2.8% ）, and then were cefoperazon/sulbactam, piperacillin/ tazobactam,gcntamicin, amikacin. Conclusions： Of the 21 antibiotics tested, Imipenem is the most sensitive one. Clinical treatment should be performed according to the results of the susceptibility test.

关 键 词：肠杆菌科 大肠埃希菌 耐药性 交叉感染 

分 类 号：R378.2[医药卫生—病原生物学]