心血管药物不良反应监测与分析  

ADRs monitoring and analysis of cardiovascular drugs

作　　者：张新萍[1] 王永铭[1] 陈斌艳[1] 

机构地区：[1]上海医科大学药学院,中国人民解放军第254医院临床药理室

出　　处：《中国药学杂志》1996年第2期90-92,共3页Chinese Pharmaceutical Journal

摘　　要：目的：了解常用心血管药物不良反应发生率，评价ＡＤＲｓ发生的危险因素。方法：采用记录应用法对心内科住院病人进行连续一年的前瞻性心血管药物不良反应监察。结果：１０１５例监察对象中，１０８例发生ＡＤＲｓ（１０．６４％），主要为轻、中度反应，Ａ型反应占９０．７４％，中途停止治疗者占发生ＡＤＲｓ，总数的３１．８４％；逻辑斯蒂单因素、多因素回归分析显示患者的肾功能状态及合并用药数与ＡＤＲｓ的发生有密切相关。结论：常用心血管药物不良反应发生率为１０．６４％，逻辑斯蒂单因素、多因素回归分析有助于确定ＡＤＲｓ发生的危险因素。OBJECTIVE:To evaluate the incidence and risk factors of cardiovascular drugs-related ADRs.METHODS:Patients hospitalized in Zhongshan and Huashan hospitals in a year,who took one or more kinds cardiovascular drugs,were observed prospectively. RESULTS:Of the 1015 patients,108(10.64%)had ADRs.The incidence of 8 drugs was 3.36%(propafenone),3.9%(diltiazelm),4.26%(nifedipine),5.62%(captopril),7.16%(digoxin),10.86%(mexlletine)3.52%(atenolol),and 4.90%(metoprolol)respectively.Type A and B reactions accounted for 90.74%and 9.26% respectively in all ADRs patients.34 patients(31.84%)discontinued treatment.Logistic analysis showed that the number of drugs and kideny function are closely related to ADRs. CONCLUSION:The incidence of cardiovascular drug-related ADRs is 10.64%. Logistic analysis helps determine risk factors of ADRs.

关 键 词：药物不良反应 心血管药物 药物流行病学 

分 类 号：R972[医药卫生—药品]