汉防己甲素对肺腺泡内动脉构形重建和肺动脉高压的作用  

^Effect of Tetrandrine on Intraacinar Pulmonary Arterial structural Remodelling and Pulmonary Hypertension

作　　者：张尚福 李俸媛 雷松 张杰 谭永淑 陈列 李钋[1] 孙本韬[1] 陈文彬 

机构地区：[1]成都公共卫生学院卫生统计学教研室,山西医学院电镜室

出　　处：《华西医科大学学报》1996年第1期59-62,共4页Journal of West China University of Medical Sciences

基　　金：国家"八;五"攻关资助

摘　　要：以野百合喊复制Ｗｉｓｔａｒ大鼠肺动脉高压模型，应用光镜和电镜观察汉防己甲素对肺腺泡内动脉构形的影响。结果表明：汉防己甲素可使肺腺泡内动脉中膜厚度、中膜厚度占血管外径百分比、肌型动脉数及部分肌型动脉数分别减少１６．４％、３０．５％、２４．３％和１６．４％，并使无肌型动脉数增加２４．７％，肺腺泡内动脉内皮细胞变性减轻，中膜胶原纤维和周细胞的增生和肌样分化减少。对其作用机制进行了探讨。Rat’s pulmonary hypertension was in-duced by a single subcutaneous injection of monocro-taline. The influences of tetrandrine (Tet)upon thestructure of intraacinar pulmonary arteries(IAPA )was studied by light and electron microscopy.The re-sults indicated that Tet reduced thickness of IAPAmedial membrane,the ratio of the thickness of IAPAmedial membrane to the diameter of IAPA,the num-ber of circular muscular artery and partially muscularartery about 16.4%,30.5%,24.3%and 16.4% re-spectively , and Tet increased the number of nonmus-cular artery about 24,7%. It also decreased the degen-eration of IAPA, collagen of medial membrane,prolife-ration and myoid differentiation of the pericyte,and it increased the number of IAPA.The authors dis-cussed why Tet caused such changes.

关 键 词：汉防己甲素 野百合碱 大鼠 肺动脉 肺动脉高压 

分 类 号：R972[医药卫生—药品]