单抗免疫导向药物3Al-DM对CFU-GM的效应试验  

THE EFFECT OF IMMUNOCONJUGATE 3Al-DM TO CFU-GM IN VITRO

作　　者：林学颜[1] 鄂学平 

机构地区：[1]中山医科大学免疫学教研室,广州510089 [2]卫生部武汉生物制品研究所

出　　处：《中国免疫学杂志》1996年第1期18-19,共2页Chinese Journal of Immunology

基　　金：加拿大国际发展研究中心(IDRC)提供部分资助

摘　　要：应用抗Ｔ淋巴细胞单抗（ＭｃＡｂ）３Ａｌ－柔霉素（ＤＭ）免疫结合物，在体外对骨髓粒－单 核细胞集落形成单位（ＣＦＵ－ＧＭ）进行导向杀伤效应试验。结果与Ｂ细胞单抗－ＤＭ结合物十分近 似。说明单抗３Ａｌ－ＤＭ对ＣＦＵ－ＧＭ没有影响，不损伤正常骨髓造血干细胞，为３Ａｌ－ＤＭ用于体外 骨髓净化提供实验依据。The immunoconjugate of monoclonal antibody (McAb) 3Al linking with daunomycin (DM) was appliped to test the effect on CFU-GM in vitro. The results demonstrated that 3Al-DM did not have any effect on CFU-GM, and could not damage normal bone marrow hemopoietic stem cells. It suggested that 3Al-DM immunoconjugate might be used for purification of bone marrow in vitro in treatment of T cell leukemia, and for host-versus-graft reaction in transplantation.

关 键 词：免疫导向药物 CFU-GM 骨髓移植 单克隆抗体 

分 类 号：R457.2[医药卫生—治疗学]