复方壬苯醇醚-9栓对家兔抗生育作用和阴道刺激性实验研究  

Effect of Nonoxynol -9 Compound on Antifertility and Vaginal Irritation in Rabbits

作　　者：张颖[1] 陈坚[1] 侯庆昌[1] 邵长凤[1] 

机构地区：[1]天津市计划生育研究所,300191

出　　处：《中国计划生育学杂志》2006年第5期287-288,共2页Chinese Journal of Family Planning

基　　金：本课题由天津市科委资助(023612911)

摘　　要：目的:观察复方壬苯醇醚-9栓对家兔的抗生育作用和阴道刺激性。方法:采用改良Eckstein方法,对性成熟雌性家兔进行阴道刺激性研究。结果:家兔抗生育实验结果表明,高、中、低剂量实验药物组的避孕率分别为 100％、80％和60％;阴道刺激炎症总分值分别为4．3、3．5、3．0。结论:在实验应用剂量下壬苯醇醚-9抗生育作用及对阴道刺激性在可接受范围内。Objective： To observe effect of Nonoxynol - 9 compound suppository on antifcrtility and vaginal irritation in the rabbits. Methods： Female mature rabbits were taken an experimentation on vaginal irritation by the method of improved Eckstein. Results： Contraceptive rate in high, middle and low dose groups was 100%, 80%, 60%, respectively. Vaginal irritation score in three groups were 4.3, 3.5, 3.0, respectively. Conclusion： Nonoxynol - 9 compound suppository is antifcrtility and its irritation in the rabbit is acceptable.

关 键 词：复方壬苯醇醚-9 抗生育作用 阴道刺激性 动物实验 

分 类 号：R96[医药卫生—药理学]