糖皮质激素对鼻息肉组织中eotaxin蛋白的影响  

Effect of glucocorticoids on eotaxin expression in nasal polyps

作　　者：朱华斌[1] 冯云海[1] 殷善开[1] 张玉君[1] 

机构地区：[1]上海交通大学附属第六人民医院耳鼻咽喉科,上海200233

出　　处：《山东大学耳鼻喉眼学报》2006年第1期21-23,26,共4页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：上海市卫生局科研基金资助项目(024034)

摘　　要：目的:探讨糖皮质激素治疗鼻息肉的可能机制。方法:随机将15例鼻息肉患者均分为强的松治疗组、地塞米松治疗组和未治疗组,以同期手术的5例鼻中隔偏曲者的下鼻甲黏膜组织作对照,用免疫组化法测定鼻息肉组织中嗜酸细胞趋化因子(eotaxin)蛋白的表达。结果:激素未治疗组eotaxin蛋白的表达比对照组显著增高(P<0.01);激素治疗组eotaxin蛋白表达下降,与未治疗组比较差异有统计学意义(P<0.01),与对照组比较差异无统计学意义(P>0.05)。结论:Eotaxin蛋白是诱导嗜酸细胞在鼻息肉组织中浸润的重要趋化因子,糖皮质激素可下调eotaxin蛋白的表达,发挥抗嗜酸细胞炎症的作用。Objective： To explore the possible mechanism of glucocorticoids on nasal polyps. Methods： Eotaxin protein expression was measured by immunohistochemical techniques in 5 nasal polypous tissue specimens following 30 mg predisone oral doses per day for 7 days, 5 nasal polypous tissue specimens following 10 mg dexamethasone intravenous drops, 5 without any treatment and compared with the results from the inferior turbinate tissue specimens. Results： The protein level of eotaxin significantly elevated in the nasal polyps compared to the controls （ P 〈 0.01）, whereas it significantly decreased in the treatment group compared with the untreatment group（ P 〈 0.01 ）, and similar to the controls（ P 〉 0.05）. Conclusion： Because eotaxin actively participates in the process of eosinophilic inflammation, glucocorticoids play an important role in anti-inflammation by down-regulation of eotaxin.

关 键 词：鼻息肉 趋化因子 嗜酸细胞 糖皮质激素类 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]