（＋），（－）和（±）棉酚在雌大鼠抗早孕作用的研究  

EFFECT OF(+),(-)AND(±)GOSSYPOL ON EARLY PREGNANCY IN RATS

作　　者：关慕贞[1] 王乃功[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药物研究所

出　　处：《药学学报》1996年第1期10-12,共3页Acta Pharmaceutica Sinica

摘　　要：妊娠第６～９天大鼠，分别ｉｇ（±）和（－）棉酚８０ｍｇ·ｋｇ^(－１)·ｄ^(－１)和４０ｍｇ·ｋｇ－１·ｄ－１，结果有明显的抗早孕作用。然而（＋）棉酚４０ｍｇ·ｋｇ－１·ｄ^(－１)对大鼠生育无明显影响。（－）棉酚３０μｇ·ｍｌ^(－１)能抑制体外培养黄体细胞孕酮的分泌。（＋）棉酚１０μｇ·ｍｌ^(－１)，能促进黄体细胞分泌孕酮。ｈＣＧ１ＩＵ·ｍｌ^(－１)能明显刺激体外培养颗粒细胞孕酮的分泌。（±）棉酚１０和３０μｇ·ｍｌ^(－1)皆能明显降低颗粒细胞对ｈＣＧ的反应性。Treatment of rats with(±)gossypol 80 mg·kg-1 or(-)gossypol 40mg·kg-1 on day6～9 of gestation terminated early pregnancy.However,(+)gossypol at thedosage of 40 mg·kg-1 was found to have no effect on gestation,(-)Gossypol at a concentration of30μg·ml-1 showed an inhibitory effect on progesterone preduction and(+)gossypol at 10μg· ml-1 caused an increase of progesterone secretion by luteal cells in vit To,A marked increase ofprogesterone level in granulosa cells was elicited by hCG,The steroidogenic response of granulosa cellsto hCG was inhibited by(±)gossypol at 10 and 30μg·ml-1。

关 键 词：棉酚 抗早孕 黄体细胞 颗粒细胞 

分 类 号：R979.2[医药卫生—药品]