乙吗噻嗪胃内滞留漂浮型缓释片的研究  

STUDIES ON ETHMOZINE SUSTAINED-RELEASE TABLET REMAINING-FLOATING IN STOMACH

作　　者：刘建平[1] 屠锡德[1] 

机构地区：[1]中国药科大学药剂学教研室

出　　处：《药学学报》1996年第1期54-58,共5页Acta Pharmaceutica Sinica

摘　　要：研制了乙吗噻嗪胃内滞留漂浮型缓释片剂（Ｅ－ＨＢＳ）。实验结果表明：本品的体外溶出符合一级动力学过程（Ｋｒ＝０．２４３６ｈ－１）；人体胃内γ－闪烁照像显示ＥＨＢＳ在胃内滞留时间长达６ｈ以上，明显长于市售普通片（ＥＣＴ１～１．５ｈ）；血药浓度经时曲线平缓持久，达到良好的缓释效果；体内外实验数据有显著的相关性（Ｐ＜０．０１）。An oral sustained-release system of cthmozm0(E-HBS)was developed.The in vitro release characteristics of E-HBS were shown primarily to be of the first order of kinetics(Kr=0.2436h-1).The γ-scintiphotographic study showed that E-HBS remained in the human stomach formore than 6 hours after ingestion,much longer than the conventional tablet(1～1.5h).The plasmaconcentration-time curve of E-HBS exhibited typical sustained-release characteristics.The percentageof drug released in iviro vs the percentage of drug release in vivo of E-HBS indicated excellent linearity.

关 键 词：乙吗噻嗪 缓释片 药代动力学 抗心律失常药 

分 类 号：R972.2[医药卫生—药品]