新型杂多化合物的体外毒性和抗流感病毒活性  

Inhibitory effects of novel heteropoly compounds on influnenza virus (H1N1) in vitro

作　　者：浦昀[1] 张欣[2] 李娟[1] 王宏芳[1] 李雪静[1] 

机构地区：[1]吉林大学公共卫生学院卫生化学教研室,吉林长春130021 [2]吉林大学药学院

出　　处：《吉林大学学报（医学版）》2006年第3期367-369,共3页Journal of Jilin University：Medicine Edition

基　　金：国家自然科学基金资助课题(20171010)

摘　　要：目的:研究3种经分子自组装合成的具有Kegin结构的新型杂多化合物的体外毒性和抗流感病毒活性。方法:采用细胞病变结合MTT法和鸡胚培养法分别测定化合物对狗肾细胞和鸡胚的毒性,并检测化合物对流感病毒A型(H1N1)的抑制活性。结果:3种化合物对狗肾细胞的TC50值和对鸡胚的LD50值均高于金刚烷胺,而反映流感病毒A型(H1N1)抑制活性的TI值均高于金刚烷胺。结论:具有Kegin结构的3种新型杂多化合物的体外毒性均低于金刚烷胺,而对流感病毒的抑制活性均高于金刚烷胺,通过分子自组装合成的新型杂多酸金刚烷胺盐达到降低毒性提高活性的目的。Objective To investigate the toxicities and inhibitory effects of three kinds of kegin-type novel heteropoly compounds which were synthesised by molecular assembly interactions on influnenza A virus （H1N1） in vitro. Methods The toxicities and anti influnenza virus activities were tested by methods of CPE MTT and chick embryos culture. Results TC50 in MDCK cells and LD50 in chick embryos of three kinds of kegin type novel heteropoly compounds were higher than those of amantadine. TI in MI）CK cells and chick embryos were both higher than that of amantadine. Conclusion The three kinds of kegin-type novel heteropoly compounds have lower toxicities and higher anti-virus effects on influnenza A virus （H1N1） than amantadine. Through chemic modifications, the toxicity of amantadine can be decreased and the activity of amantadine can be increased.

关 键 词：杂多化合物 流感病毒A型/药物作用 致细胞病理改变 病毒/药物作用 

分 类 号：R965[医药卫生—药理学]