蒺藜皂苷对麻醉开胸犬血流动力学和氧代谢的影响  

Influences of GSTT on hemodynamics and oxygen metabolism in anesthetic thoraco-opened dogs

作　　者：吕文伟[1] 曲极冰[1] 杨世杰[1] 

机构地区：[1]吉林大学基础医学院药理学教研室,吉林长春130021

出　　处：《吉林大学学报（医学版）》2006年第3期379-382,共4页Journal of Jilin University：Medicine Edition

基　　金：国家自然科学基金资助课题(30371739;30472020)

摘　　要：目的:观察蒺藜皂苷(GSTT)对麻醉开胸犬血流动力学和氧代谢的影响。方法:实验犬30只随机分为5组(每组6只):生理盐水对照组、血塞通(阳性对照药物)组及GSTT低、中、高剂量(6.26、12.52和25.00 mg.kg-1)组。采用静脉注射给药方式,检测血流动力学和氧代谢各项指标。结果:GSTT低、中及高剂量组犬心肌血流量高于对照组(P<0.01),平均动脉压、冠脉阻力、总外周血管阻力低于对照组(P<0.05或P<0.01),心肌耗氧量、心肌耗氧指数及心肌氧摄取率低于对照组(P<0.05或P<0.01)。结论:GSTT对麻醉开胸犬心脏功能有明显的调节和改善作用。Objective To observe the effet of gross saponin of tribulus terrestris （GSTT） on hemodynamics and oxygen metabolism in anesthetic thoraco-opened dogs. Methods Thirty dogs were randomly divided into negative control, positive control, and experimental groups （GSTT of 6.26, 12.52, and 25.00 mg·kg^-1） （n=6）. The administration of intravenous injection was used. The effects of GSTT on the indexes of the hemodynamics and oxygen metabolism in anesthetic thoraco-opened dogs were observed. Results Compared with controls GSTT increased myocardial blood flow （CBF） （P〈0. 01）, decreased mean arterial blood pressure （MBA）, cornary resistance （CR） and total peripheral vascular resistance （TPVR） （P〈0.05 or P〈0.01）, reduced the content and index of oxygen consumption of myocardium （P〈0.01） and myocardial oxygen uptake rate （P〈0.01 ）. Conclusion GSTT can significantly accommodate and ameliorate the heart function of anesthetic thoraco-opened dogs.

关 键 词：蒺藜/药理学 皂苷类/药理学 疾病模型 动物 血流动力学/药物作用 氧耗量/药物作用 

分 类 号：R965.1[医药卫生—药理学] R972[医药卫生—药学]