溶血磷脂酸对急性心肌梗塞大鼠并发心律失常的影响  

Effects of lysophosphatidic acid on arrhythmia in acute myocardial infarction rats

作　　者：张学新[1] 赵春燕[1] 章宏[1] 王洪[2] 孙亚琴[1] 钟国赣[1] 

机构地区：[1]吉林大学基础医学院生理学教研室,吉林长春130021 [2]吉林省长春市中心医院手术室,吉林长春130051

出　　处：《吉林大学学报（医学版）》2006年第3期407-409,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅资助课题(19990302)

摘　　要：目的:研究溶血磷脂酸(LPA)对急性心肌梗塞(AMI)大鼠并发心律失常的影响。方法:采用冠状动脉分支结扎制备AMI动物模型。将60只Wistar大鼠分成5组:假手术组,AMI动物模型组,AMI动物模型给LPA组,AMI动物模型给G蛋白受体阻断剂百日咳毒素(PTX)组,AMI动物模型给PTX及LPA组。记录各组大鼠体表心电图,将心率和室早作为主要观察指标。结果:AMI动物模型组的心动过速发生率和单位时间内室早次数与假手术组比明显增加(P<0.01),AMI动物模型给LPA组的上述2项观察指标较AMI动物模型组明显提高(P<0.05),后2组结果显示LPA的上述效应明显被PTX阻断。结论:LPA可促进AMI大鼠心律失常的发生。Objective To observe the effects of lysophosphatidic acid （LPA） on arrhythmia in acute myocardial infarction （AMI） rats. Methods AMI models were prepared by ligating the left coronary branch of rats. 60 Wistar rats were divided into 5 groups： sham-operated （SO）, AMI, AMI＋LPA, AMI＋pertussis toxin （PTX） and AMI＋PTX＋LPA. ECG were recorded, HR and VPBs were observed as important indexes. Results Incidence of tachycardia and VPBs of unit time in AMI group were increased compared with sham-operated group （P〈0.01）. Incidence of tachycardia and VPBs of unit time in AMI＋ LPA group were increased compared with AMI group （P〈0.05）. Incidence of tachycardia and VPBs of unit time in AMI＋PTX group were decreased compared with AMI＋ LPA group, it showed the effect was blocked by PTX, a G-proteincoupled receptor blocking agent. Conclusion LPA can promote the occurrence of arrbythmia in AMI rats.

关 键 词：溶血磷脂素类 心肌梗塞 心律失常 疾病模型 动物 

分 类 号：Q463[生物学—生理学] R332[医药卫生—人体生理学]