联麦氧钒对自发性高血压大鼠肾脏形态学的影响  

Influences of Bis(maltolato) oxovanadium in kidney morphology in spontaneously hypertensive rats

作　　者：孙捷[1] 王春艳[1] 杨连伟[2] 

机构地区：[1]吉林大学第一医院干部病房,吉林长春130021 [2]山东省威海市立医院,山东威海264200

出　　处：《吉林大学学报（医学版）》2006年第3期416-418,F0003,共4页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅资助课题(20010517)

摘　　要：目的:探讨联麦氧钒对自发性高血压大鼠肾脏结构的影响及机理。方法:36只自发性高血压大鼠,随机分成空白组、硝苯地平组和联麦氧钒组,采用光镜和电镜观察联麦氧钒对自发性高血压大鼠肾脏形态学的影响。结果:空白组大鼠肾小球系膜基质增生,周围毛细血管塌陷,系膜细胞增生,基底膜增厚,部分足突融合;经联麦氧钒治疗后大鼠无肾小球系膜增生及毛细血管塌陷现象,系膜细胞无增多,基底膜未见明显增厚,足突无明显融合。结论:联麦氧钒对自发性高血压大鼠肾脏具有一定的保护作用。Objective To study the effects of Bis （maholato） oxovanadium （BMOV） on renal structure of spontaneously hypertensive rats （SHRs） and its mechanism. Methods Thirty-six SHRs were divided into three groups at random： blank group, Nifedipine group and BMOV group. The light microscope and electron microscope were used to examine the pathologic changes of the kidney in rats. Results The rat glomerular mesangial expansion was found and the lumen of glomeruler capillary nearly dosed in bland group, while in BMOV group the pathological changes mentioned above were unobvious. Conclusion BMOV may have protective effects on kidney in SHRs.

关 键 词：联麦氧钒 近交SHR 肾脏/病理学 

分 类 号：R544.1[医药卫生—心血管疾病]