抑癌基因产物Rb蛋白在乳腺癌中的表达及其临床意义  

Expression of tumor suppressor gene product Rb protein in breast cancer and its clinical significance

作　　者：赵美蓉[1] 李一雷[2] 许一多[1] 高凤桐[3] 

机构地区：[1]吉林大学中日联谊医院肿瘤内科,吉林长春130033 [2]吉林大学基础医学院病理生物学教育部重点实验室,吉林长春130021 [3]吉林大学中日联谊医院核医学科,吉林长春130033

出　　处：《吉林大学学报（医学版）》2006年第3期451-453,共3页Journal of Jilin University：Medicine Edition

基　　金：教育部重点项目资助课题(20010183001)

摘　　要：目的:研究乳腺癌组织中Rb蛋白的表达及其临床意义。方法:采用S-P免疫组织化学染色法对52例乳腺癌组织和20例良性乳腺病变组织中Rb蛋白的表达进行检测。结果:Rb蛋白阴性表达率在乳腺癌组中为76.9%(40/52),显著高于良性乳腺病变组织[15.00%(3/20)](P<0.01);Rb蛋白的阴性表达与乳腺癌临床病理参数间无关联(P>0.05)。随访46例乳腺癌患者,38例Rb蛋白阴性表达者局部复发或远处转移为10.5%,而8例Rb蛋白阳性表达者则为0,两者比较差异有显著性(P<0.01)。结论:Rb蛋白的阴性表达与乳腺癌的发生有关;作为抑癌基因产物,Rb蛋白可以在蛋白质水平估计乳腺癌的病情,为临床制定治疗方案、估计病情及预后提供一个有意义的客观指标。Objective To study the expression of retinoblastoma （Rb） protein in patients with breast cancer and its significance. Methods The expressions of Rb protein were detected in 52 patients with breast cancer, 20 patients with breast fibroadenoma or breast cystic hyperplasia （control group） by S-P immunohistochemical method. Results The negative rate of Rb expression in breast cancer （76.91%） was higher than that in control group （15.00%） （P〈0.01）. There was no relationship between the negative rate of Rb expression and the clinical pathological parameters in the patients with breast cancer （P〉0.05）. Of all 46 follow-up patients with breast cancer, the peritoneal recurrence and metastatic rate was 10.53% in 38 cases of the negative expression of Rb protein, and while the rate was 0 in 8 cases of the positive expression of Rb protein, there was significant difference （P〈0.01）, Conclusion The negative expression of Rb protein may be related to the initiation of breast cancer; as an tumor suppressor genes product, Rb protein may be considered as a new clinical indicator for monitor of breast cancer and provide information for adjuvant therapy.

关 键 词：基因 肿瘤抑制 视网膜母细胞瘤蛋白质 乳腺肿瘤 

分 类 号：R737.9[医药卫生—肿瘤]