抗β_2-糖蛋白Ⅰ抗体与反复自然流产的关系  

Relationship between recurrent spontaneous abortion and anti-β_2-glycoprotein Ⅰ antibody

作　　者：刘静珠[1] 林丽[1] 胡静[1] 张士平[2] 张爽[3] 樊静[1] 

机构地区：[1]吉林大学第二医院妇产科,吉林长春130041 [2]吉林大学中日联谊医院内科,吉林长春130033 [3]吉林大学社会科学院,吉林长春132012

出　　处：《吉林大学学报（医学版）》2006年第3期486-488,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅资助课题(990569)

摘　　要：目的:探讨抗β2-糖蛋白Ⅰ抗体(anti-β2-GPⅠantibody)与反复自然流产(RSA)的关系。方法:采用酶联免疫吸附法检测81例RSA患者和39例正常妇女血清中anti-β2-GPⅠ的水平。结果:RSA组anti-β2-GPⅠ及其IgG型抗体阳性率分别为42.0%和40.8%,显著高于对照组(7.7%)(P<0.01,P<0.05);IgM型抗体阳性率与对照组比较差异无显著性(P>0.05);早期与中晚期RSA两组间及RSA 2次与RSA≥3次两组间阳性率比较差异均无显著性(P>0.05)。结论:anti-β2-GPⅠ与RSA有关,可作为RSA免疫因素的辅助诊断指标。Objective To explore the relationship between recurrent spontaneous abortion （RSA） and anti-β2- glycoprotein Ⅰ （anti-Ⅰ2-GP Ⅰ ） antibody. Methods The levels of anti-β2-GP Ⅰ antibody in serum from 81 RSA patients and 39 normal women were detected by ELISA. Results The positive rate of anti-β2-GP Ⅰ in RSA patients （42.0%） was obviously higher than that in normal women （7.7%） （P^0.01）; there was obvious difference of the positive rate of anti-β2-GP Ⅰ IgG in statistics between RSA patients （40.8%） and normal women （7.7%） （P〈0.05）, and there was no difference of the positive rate of anti-β2-GP Ⅰ IgM in statistics between RSA patients and normal women （P〉0.05）. There was no difference of the positive rate of anti-β2-GP Ⅰ in statistics between early and late, as well as between 2 times and more than 2 times abortions of RSA （P〉0.05）. Oonclusion The anti-β2-GP Ⅰ antibody is related to RSA, and it may be regarded as a immunological assistant diagnostic index for RSA.

关 键 词：流产 习惯性 抗β2-糖蛋白Ⅰ抗体 酶联免疫吸附测定 

分 类 号：R714.21[医药卫生—妇产科学]