BALB/c系裸小鼠脏器重量、脏器系数的测定  

Measurement of Organ Weight and Organ Coefficient in BALB/c Nude Mice

作　　者：练有文[1] 王晖[1] 倪少凯[2] 张志[1] 陈荣花[1] 钟秀霞[1] 黎石富[1] 

机构地区：[1]广东医学院实验动物中心,湛江524023 [2]广东医学院预防医学教研室,湛江524023

出　　处：《中国比较医学杂志》2006年第5期285-287,共3页Chinese Journal of Comparative Medicine

基　　金：广东省科技攻关项目(2004B60301011)

摘　　要：目的测定SPF级BALB/c裸小鼠脏器重量、脏器系数的生物学特性指标。方法选用成年SPF级BALB/c裸小鼠38只,雌雄各半,分别测定体重和12个脏器重量,计算脏器系数。结果雌雄裸小鼠肾、脑重量差异有显著性(P<0.01),体重、心、肝、肾上腺重量差异有显著性(P<0.05),脑系数、肾上腺系数差异有显著性(P<0.01)。肾系数差异显著(P<0.05)。雄性裸小鼠体重与心、肝、肾、脑、肾上腺、睾丸有线性关系。雌性裸小鼠体重与肝、肾、胃有线性关系。结论BALB/c雌雄裸小鼠的体重、心重量、肝重量、肾重量、脑重量、肾上腺重量、肾系数、脑系数、肾上腺系数具有差异,其体重与某些脏器存在一定的线性关系。Objective To measure the indexes of biological characteristics of organ weight and organ coefficient of SPF BALB/c nude mice. Methods 38 SPF BALB/c nude mice （ 19 males and 19 females） were chosen, and the body weight and 12 organs＇ weight were determined, then the organ coefficients were counted. Results Between female and male nude mice, the kidney weight and brain weight showed significant difference （ P 〈 0.01） and the difference of weight, heart, liver, adrenal gland weight was obvious （ P 〈 0.05 ）, the coefficient of brain, adrenal gland had remarkably significant difference （ P 〈 0.01 ） and the coefficient of kidney was obvious （ P 〈 0.05 ）. Linear analysis showed that there were obvious linear relations between body mass with heart, liver, kidney, brain, adrenal gland and testicle in male mice; there were linear relations between body weight and liver, kidney, and stomach in female mice. Conclusion Differences existed in weight, heart weight, liver weight, kidney weight, brain weight, adrenal gland weight, coefficients of kidney, brain, and adrenal gland between female and male nude mice, and there had linear relationships between body weight and organs.

关 键 词：无特定病原体 小鼠 近交BALB/c 脏器重量 脏器系数 

分 类 号：Q95-331[生物学—动物学]