前S1抗原在干扰素治疗乙型肝炎时的应用价值  

The value of Pre-S1 in the therapy of type B hepatitis with interferon

作　　者：张海谱[1] 陈玮[1] 李仕英[1] 谢晓民[1] 

机构地区：[1]白求恩国际和平医院检验科,河北石家庄050082

出　　处：《医学动物防制》2006年第5期321-323,共3页Journal of Medical Pest Control

摘　　要：目的:探讨HBV前S1抗原(Pre-S1)在干扰素治疗乙型肝炎中的应用价值。方法:56例慢性活动性肝炎(CAH)患者分为治疗组和对照组,治疗组患者接受干扰素抗病毒治疗,对照组仅做一般护肝治疗,然后测定Pre-S1相对滴度和HBVDN含量进行分析。结果:治疗组干扰素治疗后Pre-S1相对滴度显著下降,与治疗前相比差异有显著性(P<0.01);而对照组治疗后Pre-S1相对滴度下降不明显,与治疗前相比无显著性差异(P>0.05);治疗组血清Pre-S1相对滴度及HBVDNA含量变化在治疗后下降幅度有高度的一致性。结论:Pre-S1与HBVDNA检测对于评估干扰素抗病毒疗效有高度的一致性,对临床监控抗病毒治疗非常必要。Objeetive ： To explore the value of Pre--S1 in the therapy of type B hepatitis with interferon. Methods：56 chronic active hepatitis patients divide to therapy group and control group. The therapy group accept interferon anti--viral therapy, the control group only accept liver proteeting therapy, in therapy, mensure and analysis the liver function, HBV--M, the correspondence titer of Pre--S1 and content of HBVDNA. Results： The correspondence titer of Pre--S1 in therapy group descend notable after therapy, have significance difference with pretherapy（P〈0. 01）. Conehtsions： Pre--S1 and HBVDNA have high consistency in evaluation the curative effeet of interferon anti--viral, it is important to detect Pre--S1 in monitoring interferon anti--viral effect.

关 键 词：前S1抗原 干扰素 乙型肝炎病毒DNA 慢性活动性肝炎 

分 类 号：R512.62[医药卫生—内科学] R445.1[医药卫生—临床医学]