AA和MDS患者骨髓CD_(34)^+细胞表面GM-CSFR的表达及意义  

Expression and value of GM-CSF receptors on CD_(34) positive cells in bone marrow of patients with aplastic and myelodysplastic syndrome

作　　者：于媛[1] 许洪志[1] 李英[1] 李爱[1] 徐功立[1] 

机构地区：[1]山东省立医院

出　　处：《山东医药》2006年第16期1-2,共2页Shandong Medical Journal

基　　金：山东省医药卫生科技发展计划(HW116)

摘　　要：目的探讨再生障碍性贫血(AA)和骨髓增生异常综合征(M DS)患者骨髓CD3+4细胞表面粒细胞-巨噬细胞集落刺激因子受体(GM-CSFR)的表达情况。方法用流式细胞术(FCM)和单克隆抗体技术检测14例AA、23例M DS和8例非血液病患者骨髓CD3+4细胞表面的GM-CSFR表达率。结果M DS组骨髓CD3+4细胞表面GM-CSFR的表达率明显高于对照组及AA组(P<0.05),而AA组与对照组间差异无统计学意义(P>0.05)。结论AA患者造血干细胞没有质的缺陷;造血干细胞异常可能是M DS的主要发病机制之一。[Objective] To detect expression rate of granulocyte-macrophage colony-stimulating factor receptors （GM-CSFR） on CD34 positive cells in bone marrow of patients with aplastic anemia （AA） and myelodysplastic syndrome （MDS）. [Methods] The expression rates of GM-CSFR on CD34 positive cells in 14 AA patients, 23 MDS patients and 8 normal cases were detected by flow cytometry （FCM） and monoclonal antibody technique. [Results] The expression rate of GM-CSFR on CD34 positive cells in MDS group was higher than that in control group and AA group （P〈0. 05）. There was no significant difference between AA group and control group （P〈0. 05）. [Conclusion] It suggests that the quality of hematopoietic stem cells is normal in AA and the damaged quality of hematopoietic stem cells is one of the principal pathogenesis in MDS.

关 键 词：贫血 再生障碍性 骨髓增生异常综合征 抗原 CD34 粒细胞巨噬细胞集落刺激因子 受体 集落刺激因子 

分 类 号：R556.5[医药卫生—血液循环系统疾病] R551.3[医药卫生—内科学]