造血干细胞移植后死亡原因分析  

Analysis of common causes of death in hematopoietic stem cell transplantation treating hematological disorders

作　　者：葛林阜[1] 黄宁[1] 刘希民[1] 马焕文[1] 周芳[1] 郭鹏[1] 孔繁盛[1] 方圆[1] 余吉吉 

机构地区：[1]济南军区总医院,山东济南250031

出　　处：《山东医药》2006年第16期10-11,共2页Shandong Medical Journal

摘　　要：目的探讨造血干细胞移植(HSCT)治疗难治性血液病后患者的常见死亡原因。方法对我院采用HSCT治疗的117例患者临床资料进行回顾性分析。结果移植后共死亡33例(28.2%),分别死于未成功植入2例,宿主排斥移植物反应(HGV)1例,肺部感染6例,急性移植物抗宿主病(GVHD)2例,复发22例。自体移植复发率为33.3%,明显高于异体移植的7.0%(P<0.01)。结论肿瘤复发和感染是HSCT后最常见的死亡原因。有条件的情况下,应尽量选择异基因HSCT。[Objective] To explore common causes of death in hematopoietic stem cell transplantation （HSCT） treating hematological disorders. [Methods] Retrospective analysis was made on clinical data of 117 cases with HSCT in our department. [Results] 33 cases were dead post-HSCT. The cases of death were 2 cases with engraftment fail, 1 case with host-versus-graft reaction, 6 cases with pulmonary infection, 2 cases with acute graft-versus-host disease and 22 cases with replase, respectively. The relapse rate of cases with auto- HSCT was higher than that of cases with allo-HSCT （P〈0. 01）. [Conclusions] Relapse of hematological malignances and infection are very common causes of death in HSCT. To decrease relapse rate and mortality, allo-HSCT should be carried out as many as possible.

关 键 词：造血干细胞移植 死亡原因 白血病 

分 类 号：R457.7[医药卫生—治疗学] R733.7[医药卫生—临床医学]