参附注射液对心肺转流后患者心肌缺血的保护作用  

The protective effect of shenfu injection on myocardial ischemia after cardiopulmonory bypass

作　　者：张军[1] 徐瑞好[1] 周宛丽[1] 方向东[1] 李蕾[1] 余俊马[1] 

机构地区：[1]安徽省合肥市第一人民医院麻醉科,230061

出　　处：《临床麻醉学杂志》2006年第5期345-346,共2页Journal of Clinical Anesthesiology

摘　　要：目的探讨参附注射液对心肺转流(CPB)后患者心肌缺血的疗效。方法26例CPB后心电图ST段改变的患者随机均分为参附组(S组)和对照组(C组)。S组在心脏复跳后静脉滴注参附注射液1.5ml/kg。观察两组患者心肌缺血用药前及心脏复跳30、60及120min的ST段、SpO2、HR、肌酸激酶同功酶(CKMB)、心肌钙蛋白Ⅰ(cTnⅠ)、乳酸脱氢酶(LDH)及多巴胺和硝酸甘油用量之比(DA/NTG)的变化情况。结果S组患者ST段异常明显好转,SpO2改善,HR减慢,CKMB、cTnI、LDH和DA/NTG低于C组。结论参附注射液能有效减轻心肌缺血症状。Objective To investigate the protective effect of shenfu injection on myocardial ischemia after cardiopulmonary bypass （CPB）. Methods Twenty-six patients with ST segments depression were randomly divided into shenfu （group S） and control （group C） with 13 cases each. The patients in group S were transfused with shenfu injection 1.5 ml/kg after reperfusion. ST segments, SpO2, HR, cTnI, myocardial enzyme spectrum and DA/NTG were observed before myocardial ischemia, at 30,60 and 120 min during myocardial ischemia. Results Compared with group C, ST segments in group S were markedly improved during myocardial ischemia. The levels of myocardial enzyme spectrum and cTnI were much lower in group S than those in group C. Conclusion Shenfu injection combined with routine treatment has benefit effect on the myocardial ischemia.

关 键 词：参附注射液 心肺转流 心肌缺血 

分 类 号：R26[医药卫生—中医外科学]