脊髓损伤大鼠动脉电生理的变化及丙泊酚的干预作用  

Electrophysiological change of aorta in spinal cord injured rat and influence of propofol on it

作　　者：石学银[1] 邹最[1] 徐振东[2] 夏建华[3] 吕砚[1] 何星颖[1] 刘刚[1] 

机构地区：[1]上海市第二军医大学附属长征医院麻醉科,200003 [2]复旦大学附属华山医院麻醉科 [3]解放军第411医院麻醉科

出　　处：《临床麻醉学杂志》2006年第5期359-361,共3页Journal of Clinical Anesthesiology

基　　金：上海市科委基金课题(054119522);上海市卫生局基金课题(024097)

摘　　要：目的探讨大鼠高位脊髓损伤(SCI)慢性期腹主动脉对Ca2+、K+收缩力改变及丙泊酚的干预作用。方法16只大鼠随机均分为两组:脊髓T4损伤组(SCI组,咬除T4椎板,横切T4脊髓),假手术组(只暴露脊髓,不进行横切)。取大鼠腹主动脉,测定血管环对Ca2+、K+敏感性以及丙泊酚的反应性。结果与假手术组相比,SCI组大鼠腹主动脉血管环对Ca2+反应性升高(P<0.05,P<0.01),量效曲线左移,Emax增大(P<0.01);30、60mmol/LKCl刺激下,SCI组血管环收缩力较大(P<0.01);与假手术组相比,SCI组大鼠血管环对丙泊酚的舒张作用更敏感(P<0.05,P<0.01),量效曲线左移,Emin减小(P<0.01)。结论血管对Ca2+、K+等反应性升高可能是高位SCI大鼠腹主动脉高反应性的原因;SCI大鼠血管对丙泊酚的舒张作用更为敏感。Objective To observe the change of vascular reactivity of chronically spinal cord injured rat abdominal aorta to Ca^2＋、K^＋ and the infuence of propofol on vascular reactivity. Methods Sixteen rats were divided into two groups at random： sham-operated group （the fourth thoracic spinal cord was exposed but not transected） and the fourth thoracicspinal cord transection group. Then abdominal aorta was adopted to assay the sensitivity to K^＋ ,Ca^2＋ and propofol by isolated organ perfusion system. Results Compared with sham-operated rat abdominal aorta, spinalized rat abdominal aorta reactivity to Ca^2＋、K^＋ was significantly higher（P〈0.05,P〈0.01）, the dose effect curve shifted to the left,Emax augumented. Propofol had a stronger effect on vascular relaxation of spinalized rats than that of sham-operated rats （P〈0.05, P〈0.01）, the dose effect curve shifted to the left,Emin diminished （P〈0. 01）. Conclusion Vascular hyperreactivity to Ca^2＋、K^＋ may be one of the mechanisms of abdominal aorta hyperreaetivity of chronically spinalized rats. Spinalized rat aorta is more sensitive to propofol than sham-operated rat aorta.

关 键 词：脊髓损伤 自主神经反射晃常 血管反应性 丙泊酚 

分 类 号：R651.2[医药卫生—外科学] R96[医药卫生—临床医学]