比索洛尔对纤溶活性和内皮血管活性物质的影响  

Effects of Bisoprolol on Fibrinolytic Activity Endothelin Nitric Oxide and Calaitonin Gene Related Peptide in Patients with Essential Hypertension

作　　者：尹清茹 刘恒亮[2] 

机构地区：[1]河南省离休干部医疗保障办公室,郑州市450008 [2]郑州市第五人民医院,郑州市450003

出　　处：《医药论坛杂志》2006年第6期7-9,共3页Journal of Medical Forum

摘　　要：目的观察比索洛尔治疗原发性高血压(EH)时对纤溶活性、内皮素(ET)、一氧化氮(NO)、降钙素基因相关肽(CGRP)的影响。方法42例健康体检者作为正常对照组,66例EH患者用比索洛尔治疗8周,观察用药前后血组织型纤溶酶原激活物(t-PA)及其抑制物(PAI)活性,ET、NO、CGRP浓度的变化。结果EH患者t-PA活性、CGRP和NO浓度明显低于正常对照组(P<0.01),而PA I活性、ET浓度明显高于正常对照组(P<0.01),比索洛尔治疗后,血t-PA活性、NO、CGRP浓度均较治疗前显著升高(P<0.01),血ET浓度显著下降(P<0.01)。结论EH患者纤溶活性和内皮功能异常,比索洛尔可改善EH患者纤溶活性和内皮功能。Objective To investigate effects of bisoprolol on fibrinolytic activity, endothelin （ET）, nitric oxide （NO） and calaitonin gene related peptide（CGRP） in patients with essential hypertension. Methods 42 healths were assigned as normal control group,66 patients with essential hypertension were treated with bisoprolol for 8 weeks, plasma activity of tissue - type plasminogen activator（ t -PA）, plasminogen activator inhibitor （PAI） and plasma concentration of ET, NO and CGRP were measured before and 8 weeks after treatment. Results Plasma activity of t - PA and plasma concentration of NO, CGRP in patients with essential hypertension were significantly reduced than those in normal control group （ P 〈 0.01 ）, plasma activity of PAI and plasma concentration of ET in patients with essential hypertension were remarkly higher than those in normal control group（ P 〈 0.01 ）. After treatment,plasma activity of t - PA and plasma concentration of NO, CGRP were significantly elevated （ P 〈0.01 ）,plasma activity of PAI and plasma concentration of ET were remarkly decreased（ P 〈 0.01 ）. Conclusion The plasma activity of t - PA, PAI and plasma concentration of ET, NO, CGRP are abnormal in patients with essential hypertension. The bisoprolol treatment can improve fibrinolytic activity and endothelial function in patients with essential hypertension.

关 键 词：比索洛尔 纤溶活性 内皮素 一氧化氮 降钙素基因相关肽 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]