慢性乙型肝炎血小板参数与肝组织病理关系的研究  

A Study between Blood Platelet Parameters and Grading and Staging of Liver Tissues in Patients with Chronic Hepatitis B

作　　者：陈乐无[1] 明朗[1] 吴洁伟[1] 王功遂[1] 姜湘宁[1] 刘梅华[1] 谢秋里[1] 

机构地区：[1]广东省佛山市第一人民医院内六科,佛山市528300

出　　处：《医药论坛杂志》2006年第6期27-28,31,共3页Journal of Medical Forum

摘　　要：目的研究慢性乙型肝炎(CHB)患者血小板参数与肝组织病理分级分期的关系。方法用电子阻抗法检测135例慢性乙型肝炎患者血浆PLT和MPV,同时行肝组织活检并对肝组织进行炎症活动度分级(G)和纤维化程度分期(S)。结果PLT在G1、G2、G3比较差异无统计学意义(P>0.05),在G4与G1比较差异有统计学意义(P<0.01)。PLT在S0、S1、S2、S3比较差异无统计学意义(P>0.05),在S4与S0比较差异有统计学意义(P<0.01)。而MPV在G1、G2、G3比较差异无统计学意义(P>0.05),在G4与G1比较差异有统计学意义(P<0.05)。MPV在S0、S1、S2、S3、S4比较差异无统计学意义(P>0.05)。结论PLT降低,肝组织炎症活动重,肝纤维化程度高;MPV升高,肝组织炎症活动重,与肝纤维化无明显关系。Objective To study the relationship between blood platelet （PLT） parameters and grading and staging of liver tissues in patient with chronic hepatitis B （CHB）. Methods An electronic impedance method was used for PLT and mean blood platelet volume（MPV） in 135 cases CHB patients. Liver biopsy was conducted simuhaneously to determine the inflammation grade （G） and fibrosis stage of the liver tissues （S）. Results PLT were not different in G1, G2, G3 （ P 〉 0.05 ）. PLT were significant different between CA and GI （ P 〈 0.01 ）. PLT were not different in S0 ,S1 ,S2, S3 （ P 〉 0.05）. PLT were significant different between S4 and SO（ P 〈 0.01）. MPV were not different in G1 ,G2 ,G3 （ P 〉0.05）. MPV were significant different between G4 and G1 （ P 〈 0.01 ）. MPV were not different in S0 ,S1 ,S2 ,S3 ,S4 （ P 〉 0.05 ）. Conclusion The hepatic activity index and hepatic fibrosis increases as PLT level decreases. The hepatic activity index increases as MPV level increases. There is no significant correlation between MPV and hepatic fibrosis.

关 键 词：乙型肝炎 慢性 血小板计数 平均血小板体积 肝组织病理 

分 类 号：R512.62[医药卫生—内科学]