巴布剂冰辛贴镇痛效果的实验  

Experiment on the analgesic effect of cataplasma bingxin paste

作　　者：孙素兰[1] 黄东锋[2] 俞励平[1] 叶青山[1] 

机构地区：[1]中山大学药物开发中心,广东省广州市510080 [2]中山大学附属第一医院康复医学科,广东省广州市510080

出　　处：《中国临床康复》2006年第19期59-62,共4页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:对比观察改制后的新剂型巴布剂与传统型、其他同类产品消炎镇痛膏、通络祛痛贴、复方南星镇痛贴的镇痛效果。方法:实验于2004-03/2005-01在中山大学药物开发中心药理实验室完成。①选用健康昆明小白鼠240只,雄性,6周龄。②采用醋酸扭体法对比新原剂型的镇痛作用:选60只小白鼠,按体质量均衡原则随机分为5组,每组12只:新剂型低、中、高剂量组眼贴新剂型冰辛贴(以卡波姆、聚乙烯吡咯烷酮、聚丙稀酸钠、乙二胺四乙酸、甘油、水为基质,加入中药提取浸膏,制成亲水性巴布剂贴剂,药物成分同原剂型;由中山大学药物开发中心开发研究,汕头少林药业有限公司生产,批号:040517)1.0cm×1.0cm,1.5cm×1.5cm,2.0cm×2.0cm演,原剂型组眼贴原剂型冰辛贴(成分为大黄、蒲公英、延胡索、木香、三七、白芷、红花冰片、薄荷脑等组成;为黑膏药;由中山大学药物开发中心与汕头少林药业有限公司研制并生产,批号031215)1.5cm×1.5cm演,空白组:贴仅用水溶性基质涂布于无纺布上的贴剂1.5cm×1.5cm。③采用醋酸扭体法与同类产品对比镇痛作用:再取小白鼠60只按体质量均衡原则随机分为5组,每组12只:新剂型组(贴新剂型冰辛贴1.5cm×1.5cm)消炎镇痛膏组眼贴消炎镇痛膏(主要成分为薄荷脑、冰片、樟脑、颠茄流浸膏等,白云山制药有限公司,批号050206),贴药面积1.5cm×1.5cm演通络祛痛贴组眼贴通络祛痛贴(主要成分为当归、川芎、红花、山柰等,河南羚锐制药厂,批号041204)贴药面积1.5cm×1.5cm演,复方南星镇痛贴组外贴复方南星镇痛贴(主要成分为生天南星、生川乌、丁香、肉桂等江苏南星药业有限公司生产,批号050131),药物面积1.5cm×1.5cm,空白组:同上述“空白组”。④醋酸扭体法:于小白鼠臀背部脱毛区贴上相应的贴剂。48h后,腹腔注射7g/L醋酸,0.01mL/g,造成的腹膜炎疼痛模型,计数15min内扭体次�AIM： To study and compare the analgesic effect of new dose-form cataplasma bingxin paste with traditional types, other dephlogisticate and analgesic plasters, pastes of activating channels and erasing pain and Nanxing compound analgesic paste after changing. METHODS： The experiment was conducted in the Central Pharmacological Laboratory of Center for Medicine Development in Sun Yat-Sen University between March 2004 to January 2005. ①240 healthy male Kunming white mice, aged 6 months were selected, ②Acetic acid writhing method was adopted to compare the analgesic effects of new dose-form and originals： Sixty mice were selected and randomly divided into 5 groups according to the principle of balanee in body mass with 12 one in each group： low, intermediate and high dose group [mice were given of new dose-form of bingxin paste （traditional Chinese medicine was added into the stroma containing carbomer, plasdone, sodium propene acid, edathamil, glycerol and water to extract extractum and make into hydrophily new dose-form cataplasma. The components of drug were the same as original dose-form; It was studied by the Medicine Development Center of Sun Yat-Sen University, and manufactured by Shaolin Pharmaceutical Co., Ltd. in Shantou with the lot number of 040517） sized of 1.0 cm×1.0 cm, 1.5 cm×1.5 cm, 2.0 cm ×2.0 cm]. Original dose-form group [mice received bingxin paste of original dose-form （components： rheum officinale, dandelion, corydalis tuber, aucklandiae, pseudo-ginseng, angelica dehurica, carthamus tinctorious, borneol and menthol ,etc. It was a black piaster and was manufactured by the Medicine Development Center of Sun Yat- Sen University and Shantou shaolin Pharmaceutical Co., Ltd. with the lot number of 031215） 1.5 cm ×1.5 cm]. Blank group： mice only received paste of water-soluble stroma besmeared on non-spin cloth that sized of 1.5 cm×1.5 cm. ③Acetic acid writhing method was used to compare the analgesic effect with products of the same class： another 60 mice were selec

关 键 词：膏剂 疼痛/中药疗法 镇痛 

分 类 号：R441.1[医药卫生—诊断学]