代谢综合征及其代谢指标异常对患者血浆vWF与NO含量的影响  

Plasma levels of vWF and NO in patients with metabolic syndrome and their relationship with metabolic disorders

作　　者：孙雅逊[1] 胡申江[1] 张新华[1] 孙坚[2] 朱朝辉[2] 张志杰[1] 

机构地区：[1]浙江大学医学院附属第一医院心内科,浙江杭州310003 [2]浙江大学心血管研究所,浙江杭州310003

出　　处：《浙江大学学报（医学版）》2006年第3期315-318,共4页Journal of Zhejiang University(Medical Sciences)

摘　　要：目的：观测代谢综合征（MS）患者血浆中血管性假性血友病因子（vWF）和一氧化氮（NO）含量的改变，探讨其对内皮功能的影响。方法：79例患者按MS代谢指标异常数量的不同分为1～2个代谢指标异常组（n=43）和MS组（n=36），另设正常对照组（n=30），测定其血浆中vWF及NO含量，分析MS代谢指标异常与vWF、NO的关系。结果：MS患者的vWF含量高于1～2个代谢指标异常组（P〈0．05）和正常对照组（P〈0．01），1～2个代谢指标异常组的vWF值高于正常对照组（P〈0．05）；MS组的NO含量低于正常对照组（P〈0．05），1～2个代谢指标异常组的NO含量低于正常对照组（P〈0．05），MS组与1～2个代谢指标异常组无明显差异（P〉0．05），但是在两组去除糖尿病患者后，MS组的NO值低于1～2个代谢指标异常组。结论：随着代谢指标异常增多，患者内皮功能受损加重。Objective.. To measure the plasma levels of von Willebrand factor （vWF） and nitric oxide （NO） in patients with metabolic disorders and to study their relationships with the disease. Methods. The plasma levels of vWF and NO were determined in patients with metabolic syndrome （MS group, n = 36）, patients with 1 - 2 metabolic disorders （MD group, n = 43） and normal subjects （control group,n=30）. Results： The plasma vWF level was higher in MS group than that in MD group （P（0.05） and in control group （P〈0. 001）; the vWF level in MD group was higher than that in control group （P〈0. 05）. The NO level was lower in MS group and in MD group than that in control group （both P〈0.05） ,while the difference between MS and MD groups was not statistically significant （P〉0.05）. Multiple stepwise regression showed that vWF level was correlated with systolic BP （SBP）,diastolic BP（DBP） and pulse BP; that NO level was correlated with BMI, SBP and TG. Conclusion： Multiple metabolic disorders of metabolic syndrome may injure endothelial cells, and the degree of endothelial cell injury seems to be correlated with the BMI,SBP,DBP,pulse BP and TG.

关 键 词：代谢综合征X 一氧化氮/血液 von Willebrand因子/代谢 内皮 血管/病理生理学 

分 类 号：R589[医药卫生—内分泌]