墨江蜈蚣与少棘蜈蚣的比较研究──Ⅱ．药效和毒理  

COMPARISON OF Scolopendra mojiangica ZHANG et CHI AND S. subspinipes mutilans L. KOCH Ⅱ PHARMACODYNAMICS AND TOXICOLOGY

作　　者：冉永禄[1] 吴刚[1] 王金焕[1] 叶文娟[1] 迟程[1] 罗天诰 

机构地区：[1]中国科学院昆明动物研究所,云南中医学院

出　　处：《Zoological Research》1996年第1期79-83,共5页动物学研究（英文）

摘　　要：本文比较了墨江蜈蚣与少棘蜈蚣的药效学和毒理学作用，实验包括抗惊厥试验、对致病性真菌和细菌体外生长的影响、急性毒性试验和染色体畸变实验等。结果两种蜈蚣的３％醋酸提取液对所试的真菌有抑制作用但无杀真菌作用，而对细菌无抑制作用。两种蜈蚣的毒性很低，在给小鼠５０ｇ／ｋｇ的剂量下都无法测出ＬＤ５０。在２０５ｍｇ／ｋｇ条件下的致突变率与未给药的突变率接近，表明两者都无遗传毒性。The present investigation was compared on nature of pharmacodynamics and toxicology from Scolopendra mojiangica Zhang et Chi and Scolopendra subspinipes mutilans L. Koch. The experimental contents include anticonvulsive tests, effects on the growth of fungi and bacteria in vitro, acute toxicity tests, effects on animal weight and hemoglobin,chromosomal aberration tests and so on. The results showed that all of these properties of two centipedes were basically similar and this theoretically proved the possibility,that Mojiang centipede can replace the Shaoji centipede on medicine. The acute toxicities and genetic toxicities of two centipedes were low, so that these two centipedes can be used larger dosage in clinical treatment.

关 键 词：动物药 蜈蚣 墨江蜈蚣 少棘蜈蚣 药理学 毒理学 

分 类 号：R282.740.5[医药卫生—中药学]